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Anjan P. Pandey
Researcher at Purdue University
Publications - 4
Citations - 338
Anjan P. Pandey is an academic researcher from Purdue University. The author has contributed to research in topics: Lipid bilayer & Phospholipid. The author has an hindex of 4, co-authored 4 publications receiving 318 citations.
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Journal ArticleDOI
Effect of Surface Treatment on Diffusion and Domain Formation in Supported Lipid Bilayers
Kalani J. Seu,Anjan P. Pandey,Farzin Haque,Elizabeth A. Proctor,Alexander E. Ribbe,Jennifer S. Hovis +5 more
TL;DR: It will be shown that depending on the treatment method, the diffusion of the lipids can be adjusted approximately threefold without altering the composition, meaning that as the bilayer-support interaction decreases, it becomes easier to form coexisting liquid-ordered and liquid-disordered domains.
Journal ArticleDOI
Clustering of α-Synuclein on Supported Lipid Bilayers: Role of Anionic Lipid, Protein, and Divalent Ion Concentration
TL;DR: The results show that the propensity of alpha-synuclein to cluster on the membrane increases as the concentration of anionic lipid and/or protein increases, and divalent metal ions stimulate protein cluster formation by promoting lipid demixing.
Journal ArticleDOI
α-Synuclein-induced tubule formation in lipid bilayers.
TL;DR: The effects of adding wild-type α-synuclein (WT) and three familial PD mutants (A53T, A30P, and E46K) to membranes containing 15-35 mol % anionic lipid showed that WT adsorption of the protein has deleterious effects on the membrane when the anionic cholesterol concentration is less than 30 mol % or greater than 40 mol %.
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Adsorption of α-Synuclein on Lipid Bilayers: Modulating the Structure and Stability of Protein Assemblies
TL;DR: It is observed that different alterations to the system lead to different degrees of aggregation and different aggregate structures poses a challenge for drug discovery, and therapies aimed at neutralizing alpha-synuclein must target a broad range of potentially toxic, membrane-bound assemblies.