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Showing papers by "Ann M. Graybiel published in 2006"

Journal Article•DOI•
The small GTPase Rap1b regulates the cross talk between platelet integrin α2β1 and integrin αIIbβ3

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Bruno Bernardi1, Bruno Bernardi2, Gianni Francesco Guidetti1, Gianni Francesco Guidetti2, Francesca Campus1, Francesca Campus2, Jill R. Crittenden2, Jill R. Crittenden1, Ann M. Graybiel1, Ann M. Graybiel2, Cesare Balduini1, Cesare Balduini2, Mauro Torti1, Mauro Torti2 •
University of Pavia1, Massachusetts Institute of Technology2
01 Apr 2006-Blood
TL;DR: It is demonstrated that Rap1b is an important element in integrin-dependent outside-in signaling during platelet adhesion and regulates the cross talk between adhesive receptors.

79 citations

Journal Article•DOI•
Mice Lacking the Signaling Molecule, CalDAG-GEFI, Represent a Mouse Model for Leukocyte Adhesion Deficiency Type III.

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Wolfgang Bergmeier1, Wolfgang Bergmeier2, Tobias Goerge2, Tobias Goerge1, Hong-Wei Wang1, Hong-Wei Wang2, Stephen M. Cifuni2, Jill R. Crittenden3, Ann M. Graybiel3, Denisa D. Wagner2, Denisa D. Wagner1 •
Harvard University1, Massachusetts Institute of Technology2, McGovern Institute for Brain Research3
16 Nov 2006-Blood
TL;DR: It is demonstrated that CalDAG-GEFI regulates the activation of β 1 integrins in platelets and that CaldAG- GEFI-deficiency leads to a complete inhibition of arterial thrombus formation in mice.

1 citations