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Showing papers by "Ann M. Stowe published in 2012"

Journal Article•DOI•
CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke

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Ann M. Stowe1, Bradley K. Wacker2, Petra D. Cravens1, Jennifer L Perfater2, Min K. Li1, Ruilong Hu2, Angela B Freie2, Olaf Stüve1, Jeffrey M. Gidday2 •
University of Texas Southwestern Medical Center1, Washington University in St. Louis2
16 Feb 2012-Journal of Neuroinflammation
TL;DR: The early expression of CCL2 in neurons, the delayed expression in cerebral endothelial cells, and CCL1-mediated actions on circulating CCR2+ monocytes, appear to be required to establish ischemic tolerance to focal stroke in response to HPC, and thus represent a novel role for this chemokine in endogenous neurovascular protection.
Abstract: Background A brief exposure to systemic hypoxia (i.e., hypoxic preconditioning; HPC) prior to transient middle cerebral artery occlusion (tMCAo) reduces infarct volume, blood-brain barrier disruption, and leukocyte migration. CCL2 (MCP-1), typically regarded as a leukocyte-derived pro-inflammatory chemokine, can also be directly upregulated by hypoxia-induced transcription. We hypothesized that such a hypoxia-induced upregulation of CCL2 is required for HPC-induced ischemic tolerance.

81 citations