J
Jeffrey M. Gidday
Researcher at Louisiana State University
Publications - 97
Citations - 6555
Jeffrey M. Gidday is an academic researcher from Louisiana State University. The author has contributed to research in topics: Ischemia & Neuroprotection. The author has an hindex of 39, co-authored 94 publications receiving 6180 citations. Previous affiliations of Jeffrey M. Gidday include Washington University in St. Louis & University of Helsinki.
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Journal ArticleDOI
Cerebral preconditioning and ischaemic tolerance
TL;DR: Current understanding of how 'preconditioning' stimuli trigger a cerebroprotective state known as cerebral 'ischaemic tolerance' is summarized.
Journal ArticleDOI
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.
Yu Cheng,Mohanish Deshmukh,Anselm D'Costa,Joseph A. Demaro,Jeffrey M. Gidday,Aarti R. Shah,Yuling Sun,Mark F. Jacquin,Eugene M. Johnson,David M. Holtzman +9 more
TL;DR: The findings suggest that caspase inhibitors may be able to provide benefit over a prolonged therapeutic window after hypoxic-ischemic events in the developing brain, a major contributor to static encephalopathy and cerebral palsy.
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Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia.
Jeffrey M. Gidday,Yvan Gasche,Yvan Gasche,Jean C. Copin,Jean C. Copin,Aarti R. Shah,Ron Perez,Steven D. Shapiro,Pak H. Chan,Tae Sung Park +9 more
TL;DR: Overall, the findings implicate leukocytes, most likely neutrophils, as a key cellular source of MMP-9, which, in turn, promotes leukocyte recruitment, causes BBB breakdown secondary to microvascular basal lamina proteolysis, and ultimately contributes to neuronal injury after transient focal stroke.
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Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
Marcelle Bergeron,Jeffrey M. Gidday,Aimee Y. Yu,Gregg L. Semenza,Donna M. Ferriero,Frank R. Sharp,Frank R. Sharp +6 more
TL;DR: HIF‐1 activation could contribute to protective brain preconditioning, which could be used in high‐risk deliveries and other clinical situations.
Journal ArticleDOI
Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat
TL;DR: Pre-exposure to hypoxia induces endogenous adaptive mechanisms that can protect the perinatal brain from hypoxic-ischemic injury.