A
Ann Marie Craig
Researcher at University of British Columbia
Publications - 99
Citations - 15061
Ann Marie Craig is an academic researcher from University of British Columbia. The author has contributed to research in topics: Postsynaptic potential & Postsynaptic density. The author has an hindex of 58, co-authored 96 publications receiving 14182 citations. Previous affiliations of Ann Marie Craig include University of Washington & University of Illinois at Urbana–Champaign.
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Neurexins Induce Differentiation of GABA and Glutamate Postsynaptic Specializations via Neuroligins
TL;DR: The findings indicate that the neurexin-neuroligin link is a core component mediating both GABAergic and glutamatergic synaptogenesis, and differences in isoform localization and binding affinities may contribute to appropriate differentiation and specificity.
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NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo.
Yitao Liu,Tak Pan Wong,Michelle M. Aarts,Amanda Rooyakkers,Lidong Liu,Ted Weita Lai,Dong Chuan Wu,Jie Lu,Michael Tymianski,Ann Marie Craig,Yu Tian Wang +10 more
TL;DR: The present work provides a molecular basis for the dual roles of NMDA receptors in promoting neuronal survival and mediating neuronal damage and suggests that selective enhancement of NR2A-containing NMDA receptor activation with glycine may constitute a promising therapy for stroke.
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Competitive binding of α-actinin and calmodulin to the NMDA receptor
Michael Wyszynski,Jerry W. Lin,Anuradha Rao,Elizabeth A. Nigh,Alan H. Beggs,Ann Marie Craig,Morgan Sheng +6 more
TL;DR: In this article, α-Actinin-2, a member of the spectrin/dystrophin family of actin-binding proteins, is identified as a brain postsynaptic density protein that colocalizes in dendritic spines with NMDA receptors and the putative NMDA receptor-clustering molecule PSD-95.
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Neurexin-neuroligin signaling in synapse development
Ann Marie Craig,Yunhee Kang +1 more
TL;DR: Initial knockdown and knockout studies indicate that neurexins and neuroligins have an essential role in synaptic transmission, particularly at GABAergic synapses, but further studies are needed to assess the in vivo functions of these complex protein families.
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Role of Actin in Anchoring Postsynaptic Receptors in Cultured Hippocampal Neurons: Differential Attachment of NMDA versus AMPA Receptors
TL;DR: Fundamental differences in the mechanisms of receptor anchoring at postsynaptic sites are indicated, both regarding the anchoring of a single receptor in pyramidal cells versus GABAergic interneurons and regarding the Anchoring of different receptors (AMPA vs NMDA receptors) at a single class of post Synaptic sites on Pyramidal cell dendritic spines.