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Ann Orr
Researcher at National Institutes of Health
Publications - 13
Citations - 5934
Ann Orr is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA & Integrase. The author has an hindex of 11, co-authored 13 publications receiving 5552 citations. Previous affiliations of Ann Orr include Fox Chase Cancer Center.
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Journal ArticleDOI
DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139
TL;DR: In this paper, a histone H2AX species that has been phosphorylated specifically at serine 139 was found to be a major component of DNA double-stranded break.
Journal ArticleDOI
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage
Christophe E. Redon,Duane R. Pilch,Emmy P. Rogakou,Ann Orr,Noel F. Lowndes,William M. Bonner +5 more
TL;DR: It is suggested that H2A Ser 129 is an essential component for the efficient repair of DNA double‐stranded breaks (DSBs) during replication in yeast, particularly of those DSBs that do not induce the intra‐S‐phase checkpoint.
Journal ArticleDOI
Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide
TL;DR: Findings suggest that topoisomerase II inhibitors may stack with one or the other base pair flanking the enzyme cleavage sites, similar to those obtained with doxorubicin.
Journal ArticleDOI
Metal-dependent inhibition of HIV-1 integrase.
Nouri Neamati,Zhaiwei Lin,Rajeshri G. Karki,Ann Orr,Kiriana K. Cowansage,Dirk Strumberg,Godwin Pais,Johannes H. Voigt,Marc C. Nicklaus,Heather E. Winslow,He Zhao,Jim A. Turpin,Jizu Yi,Anna Marie Skalka,Terrence R. Burke,Yves Pommier +15 more
TL;DR: The design, synthesis, and antiviral activity of three novel mercaptosalicylhydrazide (MSH) derivatives are reported, suggesting that MSHs are selective inhibitors of HIV-1 IN and may serve as leads for antiviral therapeutics.
Journal Article
Rational design and molecular effects of a new topoisomerase II inhibitor, azatoxin.
François Leteurtre,Jose S. Madalengoitia,Ann Orr,Timothy J. Cuzi,Erich K. Lehnert,Timothy L. Macdonald,Yves Pommier +6 more
TL;DR: The present study shows that, in cell free systems, azatoxin induces a large number of double strand-breaks in linear Simian virus 40 and human c-myc DNA.