K
Kurt W. Kohn
Researcher at National Institutes of Health
Publications - 240
Citations - 28051
Kurt W. Kohn is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA & DNA damage. The author has an hindex of 89, co-authored 240 publications receiving 27279 citations. Previous affiliations of Kurt W. Kohn include Harvard University & American Association For Cancer Research.
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Journal ArticleDOI
A gene expression database for the molecular pharmacology of cancer
Uwe Scherf,Douglas T. Ross,Mark Waltham,Lawrence H. Smith,Jae K. Lee,Lorraine K. Tanabe,Kurt W. Kohn,William C. Reinhold,Timothy G. Myers,Darren T. Andrews,Dominic A. Scudiero,Michael B. Eisen,Edward A. Sausville,Yves Pommier,David Botstein,Patrick O. Brown,John N. Weinstein +16 more
TL;DR: Gene-drug relationships for the clinical agents 5-fluorouracil and L-asparaginase exemplify how variations in the transcript levels of particular genes relate to mechanisms of drug sensitivity and resistance.
Journal ArticleDOI
An Information-Intensive Approach to the Molecular Pharmacology of Cancer
John N. Weinstein,Timothy G. Myers,Patrick M. O'Connor,Stephen H. Friend,Albert J. Fornace,Kurt W. Kohn,Tito Fojo,Susan E. Bates,Larry Rubinstein,N. Leigh Anderson,John K. Buolamwini,William W. van Osdol,Anne Monks,Dominic A. Scudiero,Edward A. Sausville,Daniel W. Zaharevitz,Barry Bunow,Vellarkad N. Viswanadhan,George S. Johnson,Robert Wittes,Kenneth D. Paull +20 more
TL;DR: Information is being used to search for candidate anticancer drugs that are not dependent on intact p53 suppressor gene function for their activity, and it remains to be seen how effective this information-intensive strategy will be at generating new clinically active agents.
Journal Article
Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth-Inhibitory Potency of 123 Anticancer Agents
Patrick M. O'Connor,Joany Jackman,Insoo Bae,Timothy G. Myers,Saijun Fan,Masato Mutoh,Dominic A. Scudiero,Ann Monks,Edward A. Sausville,John N. Weinstein,Stephen H. Friend,Albert J. Fornace,Kurt W. Kohn +12 more
TL;DR: The analysis revealed that cells with mutant p53 sequence tended to exhibit less growth inhibition in this screen than the wild-type p53 cell lines when treated with the majority of clinically used anticancer agents: including DNA cross-linking agents, antimetabolites, and topoisomerase I and II inhibitors.
Journal ArticleDOI
Fractionation of DNA from mammalian cells by alkaline elution
TL;DR: The method of alkaline elution provides a sensitive measure of DNA single-strand length distribution in mamalian cells and is applicable to a variety of problems concerning DNA damage, repair, and replication.
Journal ArticleDOI
CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set
William C. Reinhold,Margot Sunshine,Margot Sunshine,Hongfang Liu,Sudhir Varma,Kurt W. Kohn,Joel Morris,James H. Doroshow,Yves Pommier +8 more
TL;DR: A CellMiner web application is introduced designed to improve the use of the extensive NCI-60 cell line database for discovery by creating web-based processes that are rapid, flexible, and readily applied by users without bioinformatics expertise.