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Anna C. Haagsma
Researcher at VU University Amsterdam
Publications - 8
Citations - 501
Anna C. Haagsma is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: ATP synthase & Biology. The author has an hindex of 4, co-authored 5 publications receiving 410 citations. Previous affiliations of Anna C. Haagsma include University of Amsterdam.
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Journal ArticleDOI
Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue
Anna C. Haagsma,Rooda Abdillahi-Ibrahim,Marijke J. Wagner,Klaas Krab,Karen Vergauwen,Jerome Emile Georges Guillemont,Koen Andries,Holger Lill,Anil Koul,Dirk Bald +9 more
TL;DR: Results suggest that TMC207 may not elicit ATP synthesis-related toxicity in mammalian cells, and ATP synthase, although highly conserved between prokaryotes and eukaryotes, may still qualify as an attractive antibiotic target.
Journal ArticleDOI
Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase.
Anna C. Haagsma,Anna C. Haagsma,Ioana Podasca,Ioana Podasca,Anil Koul,Koen Andries,Jerome Guillemont,Holger Lill,Holger Lill,Dirk Bald,Dirk Bald +10 more
TL;DR: The results are consistent with previous docking studies and provide experimental support for a predicted function of TMC207 in mimicking key residues in the proton transfer chain and blocking rotary movement of subunit c during catalysis.
Journal ArticleDOI
ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction.
Anna C. Haagsma,Nicole N. Driessen,Marc-Manuel Hahn,Marc-Manuel Hahn,Holger Lill,Holger Lill,Dirk Bald,Dirk Bald +7 more
TL;DR: It is shown that inverted membrane vesicles from the slow-growing model strain Mycobacterium bovis BCG are active in ATP synthesis, but ATP synthase displays no detectable ATP hydrolysis activity and does not set up a proton-motive force (PMF) using ATP as a substrate.
Journal ArticleDOI
Pyrazinoic Acid Decreases the Proton Motive Force, Respiratory ATP Synthesis Activity, and Cellular ATP Levels
Ping Lu,Anna C. Haagsma,Anna C. Haagsma,Hoang Pham,J.J. Maaskant,Selena Mol,Selena Mol,Holger Lill,Holger Lill,Dirk Bald,Dirk Bald +10 more
TL;DR: Results indicate that the predominant mechanism of killing by the first-line antituberculosis drug pyrazinamide may operate by depletion of cellular ATP reserves.
Journal ArticleDOI
Craspase is a CRISPR RNA-guided, RNA-activated protease
Chun Hu,Sam P. B. van Beljouw,Ki Hyun Nam,G. Schuler,Fran Ding,Alicia Rodríguez-Molina,Anna C. Haagsma,Menno Valk,Martin Pabst,Stan J. J. Brouns,Ailong Ke +10 more
TL;DR: Cryo-electron microscopy snapshots of Craspase are used to explain its target RNA cleavage and protease activation mechanisms and it is concluded that Craspases is a target RNA-activated protease with self-regulatory capacity.