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Anna M. Grabowska
Researcher at University of Nottingham
Publications - 93
Citations - 2867
Anna M. Grabowska is an academic researcher from University of Nottingham. The author has contributed to research in topics: Cancer & Gastrin. The author has an hindex of 27, co-authored 81 publications receiving 2362 citations. Previous affiliations of Anna M. Grabowska include Queen's University.
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Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance
Maria Secrier,Xiaodun Li,Nadeera de Silva,Matthew D. Eldridge,Gianmarco Contino,Jan Bornschein,Shona MacRae,Nicola Grehan,Maria O'Donovan,Ahmad Miremadi,Tsun-Po Yang,Lawrence Bower,Hamza Chettouh,Jason Crawte,Nuria Galeano-Dalmau,Anna M. Grabowska,John H. Saunders,Timothy J. Underwood,Timothy J. Underwood,Nicola Waddell,Andrew Barbour,Barbara Nutzinger,Achilleas Achilleos,Paul A.W. Edwards,Andy G. Lynch,Simon Tavaré,Rebecca C. Fitzgerald +26 more
TL;DR: WGS analysis of 129 cases of Esophageal adenocarcinoma demonstrated that this is a heterogeneous cancer dominated by copy number alterations with frequent large-scale rearrangements, and mutational signatures showed three distinct molecular subtypes with potential therapeutic relevance.
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In vitro models of medulloblastoma: Choosing the right tool for the job
TL;DR: Novel ways of improving the clinical relevance of in vitro models are reviewed, focusing on 3D cell culture, extracellular matrix, co-cultures with normal cells and organotypic slices.
Journal ArticleDOI
Gastrin — active participant or bystander in gastric carcinogenesis?
TL;DR: Gastrin expression is tightly regulated by two closely associated hormones, somatostatin and gastrin-releasing peptide, and aspects of their interaction may be deregulated during progression to gastric adenocarcinoma.
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Direct ex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection.
Anna M. Grabowska,Franziska Lechner,Paul Klenerman,Patrick J. Tighe,S.D. Ryder,Jonathan K. Ball,Brian J. Thomson,William L. Irving,R A Robins +8 more
TL;DR: The role of intrahepatic lymphocytes in the control of hepatitis C virus (HCV) infection and the pathology associated with it is not understood; most studies of the immunology of this infection use peripheral blood lymphocyte populations.
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Penetration and Uptake of Nanoparticles in 3D Tumor Spheroids
Aleksandra Tchoryk,Vincenzo Taresco,Richard H. Argent,Marianne Ashford,Paul Gellert,Snow Stolnik,Anna M. Grabowska,Martin C. Garnett +7 more
TL;DR: The new model combining the use of spheroids Hoechst staining and flow cytometry was a useful model for assessing NP penetration and gives useful insights into the effects of NPs' physical properties when designing nanomedicines.