Anna Maria Almerico

TL;DR: The 1,2,3-triazole skeleton can be present as a single disubstituted ring, as a linker between two molecules, or embedded in a polyheterocycle.

TL;DR: In this article, a review of the most recent examples of the three metal ions complexed with monodentate and chelating bidentate to tetradentate ligands to DNA is presented, and an attempt has also been made to rationalize the observed trend in the values of the intrinsic DNA-binding constant in terms of structural and chemical features.

TL;DR: The main goal of this study was to suggest guidelines for the rational drug design of new agonists of leptin, and identified hits could be a consistent starting point to carry out in vitro testing.

TL;DR: In this paper, a thorough characterization of the interaction of novel nickel, copper and zinc base complexes with native calf thymus DNA (ct-DNA), in buffered aqueous solution at pH 7.5, was presented.

TL;DR: Overall, the PCR inhibition and anticancer activity of the three compounds decreases in the same order 1 > 2 ≈ 3, in excellent correlation with the G4-DNA-binding affinity, implying that G 4-DNA is the biotarget for their biological activity.