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Anna Pluciennik
Researcher at Thomas Jefferson University
Publications - 22
Citations - 1998
Anna Pluciennik is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: DNA mismatch repair & Spinal and bulbar muscular atrophy. The author has an hindex of 15, co-authored 21 publications receiving 1827 citations. Previous affiliations of Anna Pluciennik include Durham University & Texas A&M University.
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Journal ArticleDOI
DNA mismatch repair: functions and mechanisms.
Journal ArticleDOI
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
Anna Pluciennik,Leonid Dzantiev,Ravi R. Iyer,Nicoleta Constantin,Farid A. Kadyrov,Paul Modrich +5 more
TL;DR: It is suggested that PCNA has two roles in MutLα function: the clamp is required for endonuclease activation, an effect that apparently involves interaction of the two proteins, and by virtue of its loading orientation, PCNA determines the strand direction of MutL α incision.
Journal ArticleDOI
DNA Mismatch Repair: Functions and Mechanisms
Journal ArticleDOI
DNA triplet repeat expansion and mismatch repair
TL;DR: This review summarizes the current knowledge of DNA mismatch repair involvement in triplet repeat expansion, which encompasses in vitro biochemical findings, cellular studies, and various in vivo transgenic animal model experiments.
Journal ArticleDOI
Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair
Anna Pluciennik,Paul Modrich +1 more
TL;DR: It is demonstrated that a protein roadblock placed on the helix between the two DNA sites inhibits MutH activation by 70–80% and that events that escape inhibition are attributable, at least in part, to diffusion of EcoRIE111Q away from its recognition site.