Anna Seelig

TL;DR: Protein molecules in solution or in protein crystals are characterized by rather well-defined structures in which α-helical regions, β-pleated sheets, etc., are the key features, and the double helix of nucleic acids has almost become the trademark of molecular biology as such.

TL;DR: It is suggested that a set of well-defined structural elements is required for an interaction with P-glycoprotein, and a high percentage of amino acids with hydrogen bonding donor side chains is found in the transmembrane sequences of P- glycoprotein relevant for substrate interaction.

TL;DR: The mean position of the deuterated segments within the membrane can be determined in most cases to a precision of better than ±1 Å, and the average orientation of the phosphocholine group in the gel state as well as the liquid crystalline state is almost parallel to the membrane surface.

TL;DR: 53 compounds with clinically established ability to cross or not to cross the blood-brain barrier by passive diffusion were characterized by means of surface activity measurements in terms of the air-water partition coefficient, Kaw, the critical micelle concentration, CMCD, and the cross-sectional area, AD.