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Annalida Bedini
Researcher at University of Urbino
Publications - 81
Citations - 1773
Annalida Bedini is an academic researcher from University of Urbino. The author has contributed to research in topics: Melatonin receptor & Melatonin. The author has an hindex of 23, co-authored 77 publications receiving 1552 citations. Previous affiliations of Annalida Bedini include Health Science University.
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Journal ArticleDOI
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.
Gilberto Spadoni,Cesarino Balsamini,Annalida Bedini,Giuseppe Diamantini,B. Di Giacomo,A. Tontini,Giorgio Tarzia,Marco Mor,Pier Vincenzo Plazzi,Silvia Rivara,Romolo Nonno,Marilou Pannacci,Valeria Lucini,Franco Fraschini,Bojidar Stankov +14 more
TL;DR: Structural-activity relationship considerations indicate that N-[1-aryl-2-(4-methoxy-1H-indol-2-yl)(C1-C2)alkyl]alkanamides represent a lead structure for this type of ligands.
Journal ArticleDOI
Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism.
Piero Sestili,Giuseppe Diamantini,Annalida Bedini,Liana Cerioni,Ilaria Tommasini,Giorgio Tarzia,Orazio Cantoni +6 more
TL;DR: The protective effects of selected members from a series of caffeic acid esters and flavonoids were tested in various toxicity paradigms and it was found that all the protective polyphenols were active at very low concentrations and their effects were observed only under those conditions in which iron chelators also afforded protection.
Journal ArticleDOI
Promotion of Non-Rapid Eye Movement Sleep and Activation of Reticular Thalamic Neurons by a Novel MT2 Melatonin Receptor Ligand
Rafael Ochoa-Sanchez,Stefano Comai,Baptiste Lacoste,Francis Rodriguez Bambico,Sergio Dominguez-Lopez,Gilberto Spadoni,Silvia Rivara,Annalida Bedini,Debora Angeloni,Franco Fraschini,Marco Mor,Giorgio Tarzia,Laurent Descarries,Gabriella Gobbi +13 more
TL;DR: The novel MT2 receptor partial agonist, N-{2-[(3-methoxyphenyl) phenylamino] ethyl} acetamide (UCM765), is here shown to selectively promote non-rapid eye movement sleep (NREMS) in rats and mice.
Journal ArticleDOI
N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands.
Silvia Rivara,Alessio Lodola,Marco Mor,Annalida Bedini,Gilberto Spadoni,Valeria Lucini,Marilou Pannacci,Franco Fraschini,Francesco Scaglione,Rafael Ochoa Sanchez,Gabriella Gobbi,Giorgio Tarzia +11 more
TL;DR: A novel series of melatonin receptor ligands, characterized by a N-(substituted-anilinoethyl)amido scaffold, along with preliminary structure-activity relationships (SARs), is presented, showing promising sleep-promoting and antianxiety properties in animal models.
Journal ArticleDOI
Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways.
Martha Lopez-Canul,Enza Palazzo,Sergio Dominguez-Lopez,Livio Luongo,Baptiste Lacoste,Stefano Comai,Debora Angeloni,Franco Fraschini,Serena Boccella,Gilberto Spadoni,Annalida Bedini,Giorgio Tarzia,Sabatino Maione,Vinicio Granados-Soto,Gabriella Gobbi +14 more
TL;DR: Data demonstrate that selective MT2 receptor partial agonists have analgesic properties through modulation of brainstem descending antinociceptive pathways, and MT2 receptors may represent a novel target in the treatment of neuropathic pain.