A
Anne D. Zurn
Researcher at University of Lausanne
Publications - 35
Citations - 4218
Anne D. Zurn is an academic researcher from University of Lausanne. The author has contributed to research in topics: Neurotrophic factors & Glial cell line-derived neurotrophic factor. The author has an hindex of 29, co-authored 35 publications receiving 4133 citations. Previous affiliations of Anne D. Zurn include University Hospital of Lausanne.
Papers
More filters
Journal ArticleDOI
Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients.
Patrick Aebischer,Myriam Schluep,Nicole Déglon,Jean-Marc Joseph,Lorenz Hirt,Bruno Heyd,Moses Goddard,Joseph P. Hammang,Anne D. Zurn,Ann C. Kato,Franco Regli,E. Edward Baetge +11 more
TL;DR: It is demonstrated that neurotrophic factors can be continuously delivered within the CSF of humans by an ex vivo gene therapy approach, opening new avenues for the treatment of neurological diseases.
Journal ArticleDOI
Isolation of multipotent neural precursors residing in the cortex of the adult human brain.
Yvan Arsenijevic,Jean-Guy Villemure,Jean-François Brunet,Jocelyne Bloch,Nicole Déglon,Corinne Kostic,Anne D. Zurn,Patrick Aebischer +7 more
TL;DR: The results indicate that the study of adult multipotent precursors is a new platform to study adult human neurogenesis, potentially generate neural cells for transplantation, and design protocols for in vivo stimulation.
Journal ArticleDOI
Self-Inactivating Lentiviral Vectors with Enhanced Transgene Expression as Potential Gene Transfer System in Parkinson's Disease
Nicole Déglon,Jack L. Tseng,Jean-Charles Bensadoun,Anne D. Zurn,Yvan Arsenijevic,L. Pereira de Almeida,Romain Zufferey,Didier Trono,Patrick Aebischer +8 more
TL;DR: In this article, a self-inactivating (SIN) lentiviral vector was modified by insertion of the posttranscriptional regulatory element of the woodchuck hepatitis virus, and particles were produced with a multiply attenuated packaging system.
Journal ArticleDOI
GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap.
Eric G. Fine,Isabelle Decosterd,Michaël Papaloïzos,Anne D. Zurn,Patrick Aebischer,Patrick Aebischer +5 more
TL;DR: S sustained delivery of GDNF and NGF to the injury site, by synthetic nerve guidance channels, allows regeneration of both sensory and motor axons over long gaps; GDNF leads to better overall regeneration in the sciatic nerve.
Journal ArticleDOI
Lentiviral vectors as a gene delivery system in the mouse midbrain : Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF
Jean-Charles Bensadoun,Nicole Déglon,Jack L. Tseng,Jean-Luc Ridet,Anne D. Zurn,Patrick Aebischer +5 more
TL;DR: In this paper, a lentiviral vector was validated as a gene delivery system in the mouse midbrain in the perspective of screening biotherapeutic molecules in mouse models of Parkinson's disease.