M
Myriam Schluep
Researcher at University Hospital of Lausanne
Publications - 89
Citations - 4139
Myriam Schluep is an academic researcher from University Hospital of Lausanne. The author has contributed to research in topics: Multiple sclerosis & Immune system. The author has an hindex of 33, co-authored 89 publications receiving 3691 citations. Previous affiliations of Myriam Schluep include University of Lausanne.
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Journal ArticleDOI
Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients.
Patrick Aebischer,Myriam Schluep,Nicole Déglon,Jean-Marc Joseph,Lorenz Hirt,Bruno Heyd,Moses Goddard,Joseph P. Hammang,Anne D. Zurn,Ann C. Kato,Franco Regli,E. Edward Baetge +11 more
TL;DR: It is demonstrated that neurotrophic factors can be continuously delivered within the CSF of humans by an ex vivo gene therapy approach, opening new avenues for the treatment of neurological diseases.
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Principal components of functional connectivity: A new approach to study dynamic brain connectivity during rest
Nora Leonardi,Nora Leonardi,Jonas Richiardi,Jonas Richiardi,Markus Gschwind,Markus Gschwind,Samanta Simioni,Jean-Marie Annoni,Jean-Marie Annoni,Myriam Schluep,Patrik Vuilleumier,Dimitri Van De Ville,Dimitri Van De Ville +12 more
TL;DR: A data-driven approach based on principal component analysis (PCA) is proposed to reveal hidden patterns of coherent FC dynamics across multiple subjects and reveal novel insights into brain connectivity dynamics and their modulation in a neurodegenerative disease.
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Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity
Jens Kuhle,Christian Barro,Giulio Disanto,Amandine Mathias,Charlotte Soneson,Guillaume Bonnier,Özgür Yaldizli,Axel Regeniter,Tobias Derfuss,Mathieu Canales,Myriam Schluep,Renaud Du Pasquier,Gunnar Krueger,Cristina Granziera +13 more
TL;DR: CSF and serum NfL levels were highly correlated, and serum concentrations were increased in RRMS, which further support longitudinal studies of serum N fL as a potential biomarker of on-going disease progression and as a possible surrogate to quantify effects of neuroprotective drugs in clinical trials.
Journal ArticleDOI
Sniff nasal pressure: a sensitive respiratory test to assess progression of amyotrophic lateral sclerosis.
TL;DR: It is concluded that Pnsn was the single respiratory test combining linear decline, sensitivity in mild disease, and feasibility in advanced disease, being easy to perform and inexpensive.
Journal ArticleDOI
Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis
Samantha Jilek,Myriam Schluep,Pascal Meylan,François Vingerhoets,Laurence Guignard,Anita Monney,Joerg Kleeberg,Géraldine Le Goff,Giuseppe Pantaleo,Renaud Du Pasquier +9 more
TL;DR: The data show high levels of CD8+ T-cell activation against EBV--but not CMV--early in the course of MS, which support the hypothesis that EBV might be associated with the onset of this disease.