Anne Ernst

TL;DR: The current knowledge of different forms of cell death induced by ionizing radiation, the multi-step process of dying cell clearance, and its immunological consequences are summarized with special regard toward the potential exploitation of these mechanisms for the improvement of tumor radiotherapy.

TL;DR: In the present review, the current status of radiation-based cancer treatment with particular focus on novel aspects and developments that will influence the field of radiation oncology in the near future is summarized and discussed.

TL;DR: Inflammation is modulated by LD‐X‐irradiation via changing the inflammatory phenotype of macrophages, and the moderate dose applied in low‐dose radiotherapy for inflammatory diseases results in an anti‐inflammatory cytokine microenvironment.

TL;DR: Evidence that protein DAMPs released by dying cells stimulate sequential recruitment of neutrophils and monocytes in vivo is provided, providing evidence that the initial steps of radiotherapy-induced anti-tumor immune priming are preferentially triggered by high single doses – at least in models of triple-negative breast cancer.

TL;DR: In this article, the authors summarize and discuss therapeutic approaches that exploit the heat shock response, either by hyperthermia or by pharmacological heat shock protein inhibition, in combination with radiotherapy, since they sensitize cancer cells to irradiation-induced cell death and at the same time have proven the potential to promote systemic anti-tumor immune mechanisms.