Showing papers by "Anne Galinier published in 2012"
TL;DR: Metabolic dysfunction is associated with a pro-inflammatory phospholipid AA/EPA ratio in plasma and ATs, and an altered adiponectin secretion that could contribute to developing metabolic syndrome.
Abstract: Background
Fatty acids (FAs) and adipokines such as adiponectin or interleukin-6 (IL-6) are known to modulate inflammation and the development of metabolic syndrome. Whether FA composition assessed in plasma triacylglycerols (TAGs), phospholipids (PLs) and non-esterified fatty acids (NEFAs) and adipose tissue (AT) PLs differed between dysmetabolic and non-dysmetabolic severely obese women remains to be established. Whether the plasma and/or AT arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio in the PL sub-fraction may be associated with adipokine AT gene expression needs to be examined.
25 citations
TL;DR: This work studies the molecular mechanisms involved in the regulation of mitochondrial biogenesis through a nutrient-sensing pathway, the Ras-cAMP pathway and pinpointed a positive feedback loop between this redox state and the control of mitochondrialBiogenesis, the first evidence for a glutathione redox control of a transcription factor involved in mitochondrial biogenic.
17 citations
TL;DR: An overview extending from physiological observations done more than fifty years ago to recent discoveries showing strategies to control essential functions in relation with metabolism in the model bacterium Bacillus subtilis is provided.
Abstract: Bacteria are able to adapt to nutrient availability in the environment. For example, when nutritional conditions are not favorable, bacterial size can be reduced and duplication time can be significantly extended in comparison to rich growth conditions. These observations suggest that essential cellular processes like cell division, morphogenesis and chromosome dynamics are highly coordinated with central metabolism to ensure the production of fit progeny. The aim of this review is to provide an overview extending from physiological observations done more than fifty years ago to recent discoveries showing strategies to control essential functions in relation with metabolism in the model bacterium Bacillus subtilis.
1 citations