Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

Microfabricated integrated circuits revolutionized computation by vastly reducing the space, labor, and time required for calculations. Microfluidic systems hold similar promise for the large-scale automation of chemistry and biology, suggesting the possibility of numerous experiments performed rapidly and in parallel, while consuming little reagent. While it is too early to tell whether such a vision will be realized, significant progress has been achieved, and various applications of significant scientific and practical interest have been developed. Here a review of the physics of small volumes (nanoliters) of fluids is presented, as parametrized by a series of dimensionless numbers expressing the relative importance of various physical phenomena. Specifically, this review explores the Reynolds number Re, addressing inertial effects; the Peclet number Pe, which concerns convective and diffusive transport; the capillary number Ca expressing the importance of interfacial tension; the Deborah, Weissenberg, and elasticity numbers De, Wi, and El, describing elastic effects due to deformable microstructural elements like polymers; the Grashof and Rayleigh numbers Gr and Ra, describing density-driven flows; and the Knudsen number, describing the importance of noncontinuum molecular effects. Furthermore, the long-range nature of viscous flows and the small device dimensions inherent in microfluidics mean that the influence of boundaries is typically significant. A variety of strategies have been developed to manipulate fluids by exploiting boundary effects; among these are electrokinetic effects, acoustic streaming, and fluid-structure interactions. The goal is to describe the physics behind the rich variety of fluid phenomena occurring on the nanoliter scale using simple scaling arguments, with the hopes of developing an intuitive sense for this occasionally counterintuitive world.

/pdf/microfluidics-fluid-physics-at-the-nanoliter-scale-4bpahtd8qa.pdf

Microfluidics: Fluid physics at the nanoliter scale

From the Publisher: 
The accessible presentation of this book gives both a general view of the entire computer vision enterprise and also offers sufficient detail to be able to build useful applications. Users learn techniques that have proven to be useful by first-hand experience and a wide range of mathematical methods. A CD-ROM with every copy of the text contains source code for programming practice, color images, and illustrative movies. Comprehensive and up-to-date, this book includes essential topics that either reflect practical significance or are of theoretical importance. Topics are discussed in substantial and increasing depth. Application surveys describe numerous important application areas such as image based rendering and digital libraries. Many important algorithms broken down and illustrated in pseudo code. Appropriate for use by engineers as a comprehensive reference to the computer vision enterprise.

Computer vision : a modern approach = 计算机视觉 : 一种现代的方法

http://experimentationlab.berkeley.edu/sites/default/files/AFMImages/butt_AFM.pdf

Force measurements with the atomic force microscope: Technique, interpretation and applications

Magnetic forces are now being utilised in an amazing variety of microfluidic applications. Magnetohydrodynamic flow has been applied to the pumping of fluids through microchannels. Magnetic materials such as ferrofluids or magnetically doped PDMS have been used as valves. Magnetic microparticles have been employed for mixing of fluid streams. Magnetic particles have also been used as solid supports for bioreactions in microchannels. Trapping and transport of single cells are being investigated and recently, advances have been made towards the detection of magnetic material on-chip. The aim of this review is to introduce and discuss the various developments within the field of magnetism and microfluidics.

Magnetism and microfluidics

Detection of Edges in Spectral Data

We discuss a general framework for recovering edges in piecewise smooth functions with finitely many jump discontinuities, where $[f](x):=f(x+)-f(x-) \neq 0$. Our approach is based on two main aspects--- localization using appropriate concentration kernels and separation of scales by nonlinear enhancement. 
To detect such edges, one employs concentration kernels, $K_\epsilon(\cdot)$, depending on the small scale $\epsilon$. It is shown that odd kernels, properly scaled, and admissible (in the sense of having small $W^{-1,\infty}$-moments of order ${\cal O}(\epsilon)$) satisfy $K_\epsilon*f(x) = [f](x) +{\cal O}(\epsilon)$, thus recovering both the location and amplitudes of all edges. As an example we consider general concentration kernels of the form $K^\sigma_N(t)=\sum\sigma(k/N)\sin kt$ to detect edges from the first $1/\epsilon=N$ spectral modes of piecewise smooth f's. Here we improve in generality and simplicity over our previous study in [A. Gelb and E. Tadmor, Appl. Comput. Harmon. Anal., 7 (1999), pp. 101--135]. Both periodic and nonperiodic spectral projections are considered. We identify, in particular, a new family of exponential factors, $\sigma^{exp}(\cdot)$, with superior localization properties. The other aspect of our edge detection involves a nonlinear enhancement procedure which is based on separation of scales between the edges, where $K_\epsilon*f(x)\sim [f](x) \neq 0$, and the smooth regions where $K_\epsilon*f = {\cal O}(\epsilon) \sim 0$. Numerical examples demonstrate that by coupling concentration kernels with nonlinear enhancement one arrives at effective edge detectors.

Detection of Edges in Spectral Data II. Nonlinear Enhancement

Gibbs ringing is a well known artifact that effects reconstruction of images having discontinuities. This is a problem in the reconstruction of magnetic resonance imaging (MRI) data due to the many different tissues normally present in each scan. The Gibbs ringing artifact manifests itself at the boundaries of the tissues, making it difficult to determine the structure of the brain tissue. The Gegenbauer reconstruction method has been shown to effectively eliminate the effects of Gibbs ringing in other applications. This paper presents the application of the Gegenbauer reconstruction method to neuro-imaging.

A method to reduce the Gibbs ringing artifact in MRI scans while keeping tissue boundary integrity

We propose a new edge detection method that is effective on multivariate irregular data in any domain. The method is based on a local polynomial annihilation technique and can be characterized by its convergence to zero for any value away from discontinuities. The method is numerically cost efficient and entirely independent of any specific shape or complexity of boundaries. Application of the minmod function to the edge detection method of various orders ensures a high rate of convergence away from the discontinuities while reducing the inherent oscillations near the discontinuities. It further enables distinction of jump discontinuities from steep gradients, even in instances where only sparse nonuniform data is available. These results are successfully demonstrated in both one and two dimensions.

/pdf/polynomial-fitting-for-edge-detection-in-irregularly-sampled-424nklvpe7.pdf

Anne Gelb

Papers

Detection of Edges in Spectral Data

Detection of Edges in Spectral Data II. Nonlinear Enhancement

A method to reduce the Gibbs ringing artifact in MRI scans while keeping tissue boundary integrity

Polynomial Fitting for Edge Detection in Irregularly Sampled Signals and Images

Robust reprojection methods for the resolution of the Gibbs phenomenon