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Anne H. Dantzig
Researcher at Eli Lilly and Company
Publications - 65
Citations - 3426
Anne H. Dantzig is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: P-glycoprotein & Prodrug. The author has an hindex of 32, co-authored 65 publications receiving 3315 citations.
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Journal Article
Reversal of P-Glycoprotein-mediated Multidrug Resistance by a Potent Cyclopropyldibenzosuberane Modulator, LY335979
Anne H. Dantzig,Robert L. Shepard,Jin Cao,Kevin L. Law,William J. Ehlhardt,Todd M. Baughman,Thomas F. Bumol,James J. Starling +7 more
TL;DR: LY335979 is an extremely potent, efficacious modulator that apparently lacks pharmacokinetic interactions with coadministered anticancer drugs and is, therefore, an exciting new agent for clinical evaluation for reversal of Pgp-associated MDR.
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Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2
Anne H. Dantzig,Linda Bergin +1 more
TL;DR: The transport of the orally absorbed cephalosporin, cephalexin, was examined in the human epithelial cell line, Caco-2 that possesses intestinal enterocyte-like properties when cultured to represent a cellular model for future studies of the dipeptide transporter.
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The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites
Susan E. Pratt,Robert L. Shepard,Ramani Kandasamy,Paul A. Johnston,William L. Perry,Anne H. Dantzig +5 more
TL;DR: The present study shows that the ATP-dependent multidrug resistance protein-5 (MRP5, ABCC5) confers resistance to 5-FU by transporting the monophosphate metabolites.
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Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.
Sean Ekins,Richard B. Kim,Brenda F. Leake,Anne H. Dantzig,Erin G. Schuetz,Lu-Bin Lan,Kazuto Yasuda,Robert L. Shepard,Mark A. Winter,John D. Schuetz,James H. Wikel,Steven A. Wrighton +11 more
TL;DR: The degree of similarity in rank ordering prediction by these inhibitor pharmacophore models generated to date confirms a likely overlap in the sites to which the three P-gp substrates used in these studies (verapamil, vinblastine, and digoxin) bind.
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Intestinal peptide transport systems and oral drug availability.
TL;DR: This review addresses the pharmaceutical potential of the intestinal peptide transport system and summarizes several studies on the mechanism and substrate structure-affinity relationship for this transport system.