E
Erin G. Schuetz
Researcher at St. Jude Children's Research Hospital
Publications - 199
Citations - 25479
Erin G. Schuetz is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Pregnane X receptor & Gene expression. The author has an hindex of 82, co-authored 199 publications receiving 24512 citations. Previous affiliations of Erin G. Schuetz include University of Texas MD Anderson Cancer Center & Research Triangle Park.
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Journal ArticleDOI
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.
Peter M. Kuehl,Jiong Zhang,Yvonne S. Lin,Jatinder K. Lamba,Mahfoud Assem,John D. Schuetz,Paul B. Watkins,Ann K. Daly,Steven A. Wrighton,Stephen D. Hall,Patrick Maurel,Mary V. Relling,Cynthia Brimer,Kazuto Yasuda,Raman Venkataramanan,Stephen C. Strom,Kenneth E. Thummel,Mark S. Boguski,Erin G. Schuetz +18 more
TL;DR: CYP3A5 was more frequently expressed in livers of African Americans than in those of Caucasians, and may be the most important genetic contributor to interindividual and interracial differences in CYP3A-dependent drug clearance and in responses to many medicines.
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Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
Stephan Teglund,Catriona McKay,Erin G. Schuetz,Jan M. van Deursen,Dimitrios J. Stravopodis,Demin Wang,Michael Brown,Sara Bodner,Gerard Grosveld,James N. Ihle,James N. Ihle +10 more
TL;DR: The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin.
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Identification of functionally variant MDR1 alleles among European Americans and African Americans
Richard B. Kim,Richard B. Kim,Brenda F. Leake,Brenda F. Leake,Edna F. Choo,Edna F. Choo,George K. Dresser,George K. Dresser,Samir V. Kubba,Samir V. Kubba,Ute I. Schwarz,Ute I. Schwarz,Amanda Taylor,Amanda Taylor,H. G. Xie,H. G. Xie,Joel McKinsey,Joel McKinsey,Sheng Zhou,Sheng Zhou,Lu-Bin Lan,Lu-Bin Lan,John D. Schuetz,John D. Schuetz,Erin G. Schuetz,Erin G. Schuetz,Grant R. Wilkinson,Grant R. Wilkinson +27 more
TL;DR: Allelic variation in MDR1 is more common than previously recognized and involves multiple SNPs whose allelic frequencies vary between populations, and some of these SNPs are associated with altered P‐glycoprotein function.
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Mapping the Genetic Architecture of Gene Expression in Human Liver
Eric E. Schadt,Cliona Molony,Eugene Chudin,Ke-Ke Hao,Xia Yang,Pek Yee Lum,Andrew Kasarskis,Bin Zhang,Susanna Wang,Christine Suver,Jun Zhu,Joshua Millstein,Solveig K. Sieberts,John Lamb,Debraj GuhaThakurta,Jonathan M. J. Derry,John D. Storey,Iliana Avila-Campillo,Mark J Kruger,Jason M. Johnson,Carol A. Rohl,Atila van Nas,Margarete Mehrabian,Thomas A. Drake,Aldons J. Lusis,Ryan Smith,F. Peter Guengerich,Stephen C. Strom,Erin G. Schuetz,Thomas H. Rushmore,Roger G. Ulrich +30 more
TL;DR: This genome-wide association study of gene expression resulted in the detection of more than 6,000 associations between SNP genotypes and liver gene expression traits, where many of the corresponding genes identified have already been implicated in a number of human diseases.
Journal ArticleDOI
Genetic contribution to variable human CYP3A-mediated metabolism
TL;DR: The human CYP3A subfamily plays a dominant role in the metabolic elimination of more drugs than any other biotransformation enzyme and may be implicated in disease risk and the metabolism of endogenous steroids or xenobiotics in these tissues.