A
Anne Pradines
Researcher at French Institute of Health and Medical Research
Publications - 73
Citations - 2859
Anne Pradines is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: RHOB & Lung cancer. The author has an hindex of 27, co-authored 60 publications receiving 2344 citations. Previous affiliations of Anne Pradines include University of Toulouse & DuPont.
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Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice.
TL;DR: RhoB is shown to be a potent suppressor of transformation and human tumor growth in nude mice and that RhoB-F is not a target for farnesyltransferase inhibitors.
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Loss of RhoB expression in human lung cancer progression
Julien Mazieres,Teresita Antonia,Ghislaine Daste,Carlos A. Muro-Cacho,Delphine Berchery,Vanessa Tillement,Anne Pradines,Said M. Sebti,Gilles Favre +8 more
TL;DR: RhoB loss of expression occurs very frequently in lung carcinogenesis, reinforcing its putative tumor suppressive activity, and raising the value of its potential use in cancer therapy.
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PD-L1 expression in circulating tumor cells of advanced non-small cell lung cancer patients treated with nivolumab.
Nicolas Guibert,Nicolas Guibert,Myriam Delaunay,Amélie Lusque,Nadia Boubekeur,Isabelle Rouquette,Estelle Clermont,Jean Mourlanette,Sandrine Gouin,Inge Dormoy,Gilles Favre,Julien Mazieres,Anne Pradines +12 more
TL;DR: Assessment of PD-L1 expression in CTCs is feasible and C TCs are more often positive than in tissue, which is associated with bad prognosis in patients treated with PD-1 inhibitors.
Journal Article
GGTI-298 Induces G0-G1 Block and Apoptosis Whereas FTI-277 Causes G2-M Enrichment in A549 Cells
Karine Miquel,Anne Pradines,Jiazhi Sun,Yimin Qian,Andrew D. Hamilton,Saïd M. Sebti,Gilles Favre +6 more
TL;DR: It was demonstrated that in the human lung adenocarcinoma A549 cells, GGTI-298 induced a G1-G0 block whereas FTI-277 induced an enrichment in the G2-M phase of the cell cycle, suggesting that protein geranylgeranylation is critical for the control of programmed cell death.
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Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells.
TL;DR: It is demonstrated that isoprenoid-induced apoptosis was preceded by an arrest in G0/G1 phase, and the mevalonate pathway, leading notably to prenylated proteins, might be linked to the control of cell proliferation through the regulation of phosphatidylcholine biosynthesis.