A
Anthony J. Croatt
Researcher at Mayo Clinic
Publications - 73
Citations - 5461
Anthony J. Croatt is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Kidney & Heme oxygenase. The author has an hindex of 40, co-authored 70 publications receiving 5128 citations. Previous affiliations of Anthony J. Croatt include University of Minnesota & Ochsner Health System.
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Journal ArticleDOI
Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury.
Xiangyang Dong,Sundararaman Swaminathan,Lori A. Bachman,Anthony J. Croatt,Karl A. Nath,Matthew D. Griffin +5 more
TL;DR: In vivo depletion of DCs from the kidney substantially attenuated TNF secretion by total and CD45(+ve) cells following IRI, uncovering a role for resident F4/80( +ve) DCs as the predominant secretors of TNF within 24 h of IRI.
Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion
TL;DR: In this paper, the contribution of dendritic cells (DCs) to early production of TNF and other inflammatory mediators was investigated in renal ischemia-reperfusion injury (IRI) patients.
Journal ArticleDOI
The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo.
TL;DR: The induction of HO-1 is an indispensable response in protecting against acute heme protein toxicity in vivo, and doses of hemoglobin precipitate rapidly developing, acute renal failure and marked mortality inHO-1 -/- mice.
Journal ArticleDOI
Induction of heme oxygenase in toxic renal injury: A protective role in cisplatin nephrotoxicity in the rat
TL;DR: It is confirmed that tin protoporphyrin prevented the increase in heme oxygenase activity induced by cisplatin, which was associated with increased kidney heme content and ferritin content.
Journal ArticleDOI
Heme protein-induced chronic renal inflammation: suppressive effect of induced heme oxygenase-1.
Karl A. Nath,Karl A. Nath,Gregory M. Vercellotti,Gregory M. Vercellotti,Joseph P. Grande,Joseph P. Grande,Hiroko Miyoshi,Hiroko Miyoshi,Hiroko Miyoshi,Carlos V. Paya,Carlos V. Paya,Carlos V. Paya,J. Carlos Manivel,J. Carlos Manivel,Jill J. Haggard,Jill J. Haggard,Jill J. Haggard,Anthony J. Croatt,Anthony J. Croatt,Anthony J. Croatt,William D. Payne,William D. Payne,Jawed Alam,Jawed Alam,Jawed Alam +24 more
TL;DR: It is concluded that up-regulation of HO-1 occurs in the kidney in humans and rats repetitively exposed to heme proteins, which represents an anti-inflammatory response since the genetic deficiency ofHO-1 markedly increases activation of NF-kappaB, MCP-1 expression, and tubulointerstitial cellular inflammation.