G
Gregory M. Vercellotti
Researcher at University of Minnesota
Publications - 321
Citations - 20692
Gregory M. Vercellotti is an academic researcher from University of Minnesota. The author has contributed to research in topics: Endothelial stem cell & Endothelium. The author has an hindex of 73, co-authored 305 publications receiving 19370 citations. Previous affiliations of Gregory M. Vercellotti include Medical College of Wisconsin & Hennepin County Medical Center.
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Journal ArticleDOI
Ferritin: a cytoprotective antioxidant strategem of endothelium.
György Balla,Harry S. Jacob,József Balla,Murray D. Rosenberg,Karl A. Nath,Fred S. Apple,John W. Eaton,Gregory M. Vercellotti +7 more
TL;DR: It is concluded that endothelium and perhaps other cell types may be protected from oxidant damage through the iron sequestrant, ferritin.
Journal ArticleDOI
C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor
Jaroslav Cermak,Nigel S. Key,Ronald R. Bach,József Balla,Harry S. Jacob,Gregory M. Vercellotti +5 more
TL;DR: C-reactive protein (CRP), an acute- phase reactant that markedly increases its serum concentration in response to inflammatory stimuli, induced monocytes to express tissue factor (TF), a potent procoagulant.
Journal ArticleDOI
Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat
Karl A. Nath,György Balla,Gregory M. Vercellotti,József Balla,Harry S. Jacob,Michael Levitt,Mark E. Rosenberg +6 more
TL;DR: In vivo evidence is provided that induction of heme oxygenase coupled to ferritin synthesis is a rapid, protective antioxidant response, suggesting a therapeutic strategy for populations at a high risk for rhabdomyolysis.
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Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.
TL;DR: It is demonstrated that reduced ferrohemoglobin, while relatively innocuous to cultured endothelial cells, when oxidized to ferrihemoglobin (methemoglobin), greatly amplifies oxidant (H2O2)-mediated endothelial-cell injury.
Journal ArticleDOI
Pro-oxidant and cytotoxic effects of circulating heme
Viktória Jeney,József Balla,Akihiro Yachie,Zsuzsa Varga,Gregory M. Vercellotti,John W. Eaton,György Balla +6 more
TL;DR: It is concluded that hemoglobin, when oxidized in plasma, can be indirectly cytotoxic through the generation of oxidized LDL by released heme and that, in response, the intracellular defense-HO-1 and ferritin-is induced.