Anthony Joseph Hayes

TL;DR: It is shown that loss of Apc acutely activates Wnt signaling through the nuclear accumulation of beta-catenin, which perturbs differentiation, migration, proliferation, and apoptosis, such that Apc-deficient cells maintain a "crypt progenitor-like" phenotype.

TL;DR: A series of lipophilic and hydrophilic fac tricarbonyl rhenium bisimine complexes have been prepared and their membrane-permeabilities explored in liposomes and their potential for application in fluorescence microscopy cell imaging demonstrated in the first application of MLCT-fluorescent Rhenium complexes in cell imaging.

TL;DR: This study combines genetic approaches and intervention strategies to describe a fundamental requirement for IL-6-mediated STAT3 signaling in orchestrating the inflammatory infiltrate in monoarticular and systemic models of experimental arthritis, and suggests that selective inhibition ofIL-6 trans signaling may provide a more refined intervention strategy for blocking IL- 6-driven proarthritic activities.

TL;DR: FISH was used in combination with confocal laser scanning microscopy to detect and characterize the spatial distribution of biofilm-forming bacteria which predominate within human chronic skin wounds and demonstrated that P. aeruginosa was predominant.

TL;DR: Overall, the data lends further support to the notion of articular cartilage growing by apposition from the articular surface rather than by interstitial mechanisms.