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Anthony K.C. Chan
Researcher at McMaster Children's Hospital
Publications - 405
Citations - 17396
Anthony K.C. Chan is an academic researcher from McMaster Children's Hospital. The author has contributed to research in topics: Antithrombin & Heparin. The author has an hindex of 64, co-authored 373 publications receiving 15370 citations. Previous affiliations of Anthony K.C. Chan include Hamilton Health Sciences & McMaster University.
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Journal ArticleDOI
Neonatal aortic thrombosis: a comprehensive review.
TL;DR: A classification system to standardize reporting of neonatal aortic thrombosis, as well as a treatment decision tree, and a clinical guide for the treatment of thromBosis in children are suggested.
Journal ArticleDOI
Urgent Clinical Challenges in Children With Ischemic Stroke Analysis of 1065 Patients From the 1-800-NOCLOTS Pediatric Stroke Telephone Consultation Service
Stefan Kuhle,Lesley G. Mitchell,Maureen Andrew,Anthony K.C. Chan,Patricia Massicotte,Margaret Adams,Gabrielle deVeber +6 more
TL;DR: Research is urgently needed in pediatric stroke to provide direction for management in “real-life” settings and should address the unique challenges within different stroke types and include observational studies addressing investigation of the child with AIS.
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Surface modification with an antithrombin-heparin complex for anticoagulation: studies on a model surface with gold as substrate.
TL;DR: It was shown that ATH-immobilized surfaces bound significantly greater amounts from both buffer and plasma than the analogous heparinized surfaces, indicating the enhanced anticoagulant potential of ATH for biomaterial surface modification.
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Bleeding disorders in neonates
TL;DR: Bleeding disorders may present during the neonatal period, however, absent patient history along with unique physical signs, physiologically decreased levels of plasma proteins and laboratory variations of platelet function tests may render any diagnosis difficult to establish.
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Immobilization of an antithrombin-heparin complex on gold: anticoagulant properties and platelet interactions.
TL;DR: The anticoagulant properties and platelet interactions of gold surfaces modified with an antithrombin-heparin (ATH) complex are reported and Platelet adhesion from flowing whole blood was found to be reduced on PEO- and ATH-modified surfaces compared to bare gold.