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Anthony K.C. Chan
Researcher at McMaster Children's Hospital
Publications - 405
Citations - 17396
Anthony K.C. Chan is an academic researcher from McMaster Children's Hospital. The author has contributed to research in topics: Antithrombin & Heparin. The author has an hindex of 64, co-authored 373 publications receiving 15370 citations. Previous affiliations of Anthony K.C. Chan include Hamilton Health Sciences & McMaster University.
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Journal ArticleDOI
Isoform composition of antithrombin in a covalent antithrombin-heparin complex.
TL;DR: A covalent AT-heparin complex (ATH) is prepared that has increased intravenous half-life, reduced bleeding risk, and can directly inhibit clot-bound thrombin, and structural analysis is required to further develop this promising antithrombotic agent.
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Neonatal and infant pulmonary thromboembolism: a literature review.
TL;DR: A scientific review is conducted to determine if the presentation, diagnosis, treatment and outcomes of neonates and infants with PTE are consistent across studies and to develop an algorithm to establish the diagnosis and management of the condition based on current information.
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Antithrombin-heparin covalent complex reduces microemboli during cardiopulmonary bypass in a pig model.
Petr Klement,Petr Klement,Leslie R. Berry,Peng Liao,Henry Wood,Paul Tressel,Lesley J. Smith,Nihal Haque,J. I. Weitz,Jack Hirsh,Nethnapha Paredes,Anthony K.C. Chan +11 more
TL;DR: The hypotheses that the majority of HITS represent thromboemboli and that ATH reduces emboli formation during CPB are supported, suggesting microemboli in the brain could be a contributing factor to postoperative neurocognitive dysfunction.
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Biodistribution of covalent antithrombin-heparin complexes
TL;DR: In summary, systemic elimination of ATH is greatly influenced by the form of AT in the complex, with liver uptake and degradation playing a major role.
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Transfusion premedication practices among pediatric health care practitioners in Canada: results of a national survey
TL;DR: Although not supported by strong evidence, premedication (pretransfusion medication) is commonly prescribed to patients who have had a transfusion reaction.