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Anthony Maxwell
Researcher at John Innes Centre
Publications - 217
Citations - 13414
Anthony Maxwell is an academic researcher from John Innes Centre. The author has contributed to research in topics: DNA gyrase & DNA supercoil. The author has an hindex of 62, co-authored 206 publications receiving 12249 citations. Previous affiliations of Anthony Maxwell include University of Oxford & University of California, Berkeley.
Papers
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Journal ArticleDOI
DNA Gyrase: Structure and Function
Richard J. Reece,Anthony Maxwell +1 more
TL;DR: In this review, the current knowledge concerning DNA gyrase is summarized by addressing a wide range of aspects of the study of this enzyme.
Journal ArticleDOI
Crystal structure of an N-terminal fragment of the DNA gyrase B protein.
TL;DR: The crystal structure of an N-terminal fragment of the Escherichia coli DNA gyrase B protein, com-plexed with a nonhn/drolysable ATP analogue, has been solved at 2.5 Å resolution.
Journal ArticleDOI
Crystal structure of the breakage-reunion domain of DNA gyrase
Joo H. Morais Cabral,Andrew P. Jackson,Clare V. Smith,Nita Shikotra,Anthony Maxwell,Robert C. Liddington +5 more
TL;DR: The crystal structure of the breakage-reunion domain of DNA gyrase at 2.8 A resolution was presented in this paper, where it was shown that the two structures represent two principal conformations that participate in the enzymatic pathway.
Journal ArticleDOI
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.
TL;DR: Known gyrase-specific drugs and toxins are reviewed and the prospects for developing new antibacterials targeted to this enzyme are assessed.
Journal ArticleDOI
DNA gyrase as a drug target
TL;DR: DNA gyrase is a remarkable enzyme, catalysing the seemingly complex reaction of DNA supercoiling, and it is a good target for antibacterial agents.