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Shantanu Karkare
Researcher at Novartis
Publications - 8
Citations - 1137
Shantanu Karkare is an academic researcher from Novartis. The author has contributed to research in topics: DNA gyrase & DNA supercoil. The author has an hindex of 7, co-authored 8 publications receiving 1016 citations. Previous affiliations of Shantanu Karkare include Norwich Research Park & John Innes Centre.
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Journal ArticleDOI
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.
TL;DR: Known gyrase-specific drugs and toxins are reviewed and the prospects for developing new antibacterials targeted to this enzyme are assessed.
Journal ArticleDOI
Highly specific gene silencing by artificial microRNAs in the unicellular alga Chlamydomonas reinhardtii
Attila Molnar,Andrew R. Bassett,Eva C. Thuenemann,Frank Schwach,Shantanu Karkare,Stephan Ossowski,Detlef Weigel,David C. Baulcombe +7 more
TL;DR: A novel artificial miRNA system based on ligation of DNA oligonucleotides that can be used for specific high-throughput gene silencing in green algae is developed.
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Promising nucleic acid analogs and mimics: characteristic features and applications of PNA, LNA, and morpholino.
TL;DR: The nucleic acid analogs provide an advantage to design and implementation, therapies, and research assays, which were not implemented due to limitations associated with standard nucleic acids chemistry.
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The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.
Shantanu Karkare,Terence T.H. Chung,Frédéric Collin,Lesley A. Mitchenall,Adam R. McKay,Sandra J. Greive,J.J.M. Meyer,Namrita Lall,Anthony Maxwell +8 more
TL;DR: Diospyrin and other naphthoquinones are found to be inhibitors of the supercoiling reaction catalyzed by M. tuberculosis gyrase and other gyrases and have potential as antibacterial compounds against TB.
Journal ArticleDOI
An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p
Dominic Hoepfner,Shantanu Karkare,Stephen B. Helliwell,Martin Pfeifer,Markus Trunzer,Sophie De Bonnechose,Alfred Zimmerlin,Jianshi Tao,Daryl L. Richie,Andreas Hofmann,Stefan Reinker,Mathias Frederiksen,N. Rao Movva,Jeffrey A. Porter,Neil S. Ryder,Christian N. Parker +15 more
TL;DR: This work has identified non-azole Erg11p inhibitors, using a systematic approach for ligand and target characterization, and Candida strains carrying azole-resistant alleles of ERG11 are also resistant to the compounds in this study.