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Antje Flieger
Researcher at Robert Koch Institute
Publications - 129
Citations - 3561
Antje Flieger is an academic researcher from Robert Koch Institute. The author has contributed to research in topics: Legionella pneumophila & Outbreak. The author has an hindex of 34, co-authored 118 publications receiving 2974 citations. Previous affiliations of Antje Flieger include University of Würzburg & University of Tübingen.
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Bacterial Sphingomyelinases and Phospholipases as Virulence Factors
Marietta Flores-Díaz,Laura Monturiol-Gross,Claire E. Naylor,Alberto Alape-Girón,Antje Flieger +4 more
TL;DR: The identification of sphingomyelinases and phospholipases important for bacterial pathogenesis and the development of inhibitors for these enzymes could generate candidate vaccines and therapeutic agents, which will diminish the impacts of the associated human and animal diseases.
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NAIP and Ipaf Control Legionella pneumophila Replication in Human Cells
Maya Vinzing,Julia Eitel,Juliane Lippmann,Andreas C. Hocke,Janine Zahlten,Hortense Slevogt,Philippe Dje N'Guessan,Stefan Günther,Bernd Schmeck,Stefan Hippenstiel,Antje Flieger,Norbert Suttorp,Bastian Opitz +12 more
TL;DR: It is demonstrated that flagellin-deficient L. pneumophila replicate more efficiently in human THP-1 macrophage, primary monocyte-derived macrophages, and alveolar macrophaging, and in A549 lung epithelial cells compared with wild-type bacteria.
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Legionella pneumophila Induces IFNβ in Lung Epithelial Cells via IPS-1 and IRF3, Which Also Control Bacterial Replication
Bastian Opitz,Maya Vinzing,Vincent van Laak,Bernd Schmeck,Guido Heine,Stefan Günther,Robert Preissner,Hortense Slevogt,Philippe Dje N′Guessan,Julia Eitel,Torsten Goldmann,Antje Flieger,Norbert Suttorp,Stefan Hippenstiel +13 more
TL;DR: A critical role of IPS-1, IRF3, and IFNβ in Legionella infection of lung epithelium is demonstrated and bacterial multiplication assays in small interfering RNA-treated cells indicated that IPS- 1, IRFs 3, andIFNβ were essential for the control of intracellular replication of L. pneumophila in lung epithelial cells.
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Patatin-like proteins: a new family of lipolytic enzymes present in bacteria?
Sangeeta Banerji,Antje Flieger +1 more
TL;DR: ExoU, a type III secreted cytotoxin and virulence factor of Pseudomonas aeruginosa with lipase as well as phospholipase A activity, contains defined regions of protein homology to potato patatin B2 and cPLA2 with a putative catalytic Ser-Asp dyad.
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Update: Multinational listeriosis outbreak due to ‘Quargel’, a sour milk curd cheese, caused by two different L. monocytogenes serotype 1/2a strains, 2009-2010
Rainer Fretz,Juliane Pichler,U. Sagel,Peter Much,Werner Ruppitsch,Ariane Pietzka,Anna Stöger,Steliana Huhulescu,S Heuberger,G. Appl,Dirk Werber,Klaus Stark,Rita Prager,Antje Flieger,Renata Karpíšková,Günter Pfaff,Franz Allerberger +16 more
TL;DR: A second strain of L. monocytogenes serotype 1/2a (clone 2) spread by this product could be linked to further 13 cases in Austria (two fatal), six in Germany (one fatal) and one case in the Czech Republic, with onset of disease from December 2009 to end of February 2010.