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Antoinette V. Buys
Researcher at University of Pretoria
Publications - 12
Citations - 597
Antoinette V. Buys is an academic researcher from University of Pretoria. The author has contributed to research in topics: Fibrin & Thrombin. The author has an hindex of 10, co-authored 12 publications receiving 512 citations.
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Journal ArticleDOI
Changes in red blood cell membrane structure in type 2 diabetes: a scanning electron and atomic force microscopy study
Antoinette V. Buys,Mia-Jean Van Rooy,Prashilla Soma,Dirk van Papendorp,Boguslaw Lipinski,Etheresia Pretorius +5 more
TL;DR: It is shown that the combined AFM and SEM analyses of RBCs give valuable information about the disease status of patients with diabetes, as this cell’s health status is crucial to the overall wellness of the diabetic patient.
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Eryptosis as a marker of Parkinson's disease
Etheresia Pretorius,Albe C. Swanepoel,Antoinette V. Buys,Natasha Vermeulen,Wiebren Duim,Douglas B. Kell +5 more
TL;DR: It is shown that the RBCs of PD patients are indeed rather dramatically deranged in their morphology, exhibiting eryptosis (a kind of programmed cell death), and this morphological indicator may have useful diagnostic and prognostic significance.
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Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics
Etheresia Pretorius,Janette Bester,Natasha Vermeulen,Sajee Alummoottil,Prashilla Soma,Antoinette V. Buys,Douglas B. Kell +6 more
TL;DR: The axial ratio of the erythrocytes of poorly controlled type 2 diabetics was significantly increased, and that their fibrin morphologies were again highly aberrant, but these could be reversed, to some degree, by the addition of the iron chelators deferoxamine (DFO) or deferasirox (DFX).
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High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease
TL;DR: It is argued that high ferritin levels may contribute to an accelerated pathology in AD, and the possibility both of an early diagnosis and some means of treating or slowing down the progress of this disease is suggested.
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From the Cover: An Investigation of the Genotoxicity and Interference of Gold Nanoparticles in Commonly Used In Vitro Mutagenicity and Genotoxicity Assays
TL;DR: It is shown that false positive results obtained with Comet assay may have been due to the possibility of direct contact between the residual, intracellular AuNPs and DNA during the assay procedure, and the chromosome aberration and micronucleus assays are better suited to assess the genotoxic effects of nanoparticles due to low probability of such direct contact occurring.