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Anton Filikov
Publications - 13
Citations - 467
Anton Filikov is an academic researcher. The author has contributed to research in topics: Nucleic acid & Tumor necrosis factor alpha. The author has an hindex of 8, co-authored 13 publications receiving 442 citations.
Papers
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Journal ArticleDOI
Inactivation of TNF signaling by rationally designed dominant-negative TNF variants.
Paul Michael Steed,Malú G. Tansey,Jonathan Zalevsky,Eugene Zhukovsky,John R. Desjarlais,David E. Szymkowski,Christina Abbott,David F. Carmichael,Cheryl Chan,Lisa Cherry,Peter Cheung,Arthur J. Chirino,Hyo H. Chung,Stephen K. Doberstein,Araz Eivazi,Anton Filikov,Sarah X. Gao,Rend S. Hubert,Marian Hwang,Linus Hyun,Sandhya Kashi,Alice Kim,Esther Kim,James Kung,Sabrina P. Martinez,T. Umesh S. Muchhal,Duc-Hanh T. Nguyen,C. O'Brien,Donald O'keefe,Karen Singer,Omid Vafa,Jost Vielmetter,Sean Yoder,Bassil I. Dahiyat +33 more
TL;DR: Structural-based design is used to engineer variant TNF proteins that rapidly form heterotrimers with native TNF to give complexes that neither bind to nor stimulate signaling through TNF receptors, and TNF is inactivated by sequestration.
Journal ArticleDOI
Computational stabilization of human growth hormone.
Anton Filikov,Robert J. Hayes,Peizhi Luo,Diane M. Stark,Cheryl Chan,Anirban Kundu,Bassil I. Dahiyat +6 more
TL;DR: The redesigned hGH computationally to improve its thermostability was redesigned using a previously developed combinatorial optimization algorithm based on the dead‐end elimination theorem and shows the utility of the free energy function in automated protein design.
Patent
Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders
Bassil I. Dahiyat,John R. Desjarlais,Anton Filikov,Umesh Muchhal,Malú G. Tansey,Jonathan Zalevsky +5 more
TL;DR: In this article, a novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins were proposed for use in the treatment of TNF -alpha related disorders.
Patent
TNF-alpha VARIANTS PROTEINS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS
Bassil I. Dahiyat,John R. Desjarlais,Anton Filikov,Umesh Muchhal,Malú G. Tansey,Jonathan Zalevsky +5 more
TL;DR: In this paper, a novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins were proposed for use in the treatment of TNF -alpha related disorders.
Patent
Design and discovery of protein based tnf-.alpha. variants for the treatment of tnf-.alpha. related disorders
Bassil I. Dahiyat,Anton Filikov +1 more
TL;DR: In this paper, the use of the novel proteins in the treatment of TNF-α related disorders, such as rheumatoid arthritis, has been discussed, which relates to novel proteins with TNFα antagonist activity and nucleic acids encoding these proteins.