Stephen K. Doberstein

TL;DR: A comprehensive set of recombinant secreted proteins and the extracellular domains of transmembrane proteins, which constitute most of the protein components of the Extracellular space, are produced, useful for discovering new ligands and receptors and assessing the functional selectivity ofextracellular regulatory proteins.

TL;DR: In this article, the present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized FC variants, and is related to our work.

TL;DR: Structural-based design is used to engineer variant TNF proteins that rapidly form heterotrimers with native TNF to give complexes that neither bind to nor stimulate signaling through TNF receptors, and TNF is inactivated by sequestration.

TL;DR: It is suggested that the in vitro effects on actin polymerization may be explained by a complex mechanism that includes weak capping of filament ends and catalytic poisoning of nucleation, and although platelets contain only 1profilin for every 5-10 actin molecules, these complex reactions may allow substoichiometric profilin to have an important influence on act in assembly.

TL;DR: DN-TNFs are established as the first selective inhibitors of solTNF, demonstrate that inflammation in mouse arthritis models is primarily driven by solT NF, and suggest that the maintenance of tmTNF activity may improve the therapeutic index of future anti-inflammatory agents.