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Antonella Lavagetto
Researcher at Ente Ospedaliero Ospedali Galliera
Publications - 4
Citations - 467
Antonella Lavagetto is an academic researcher from Ente Ospedaliero Ospedali Galliera. The author has contributed to research in topics: Deferasirox & Liver biopsy. The author has an hindex of 4, co-authored 4 publications receiving 423 citations.
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Journal ArticleDOI
Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload.
Antonio Piga,Renzo Galanello,Gian Luca Forni,Maria Domenica Cappellini,Raffaella Origa,Antonietta Zappu,Guido Donato,Elena Bordone,Antonella Lavagetto,Laura Zanaboni,Romain Sechaud,Nicola Hewson,John Ford,Herbert Opitz,Daniele Alberti +14 more
TL;DR: Deferasirox showed a plasma elimination half-life of 8-16 hours, supporting its once-daily administration, and was well tolerated and showed similar efficacy to DFO 40 mg/kg in terms of decreases in LIC.
Journal ArticleDOI
Phase II clinical evaluation of deferasirox, a once-daily oral chelating agent, in pediatric patients with beta-thalassemia major.
Renzo Galanello,Antonio Piga,Gian Luca Forni,Yves Bertrand,Maria Loreta Foschini,Elena Bordone,GiovanBattista Leoni,Antonella Lavagetto,Antonietta Zappu,Filomena Longo,Henry Maseruka,Nicola Hewson,Romain Sechaud,Rossella Belleli,Daniele Alberti +14 more
TL;DR: The dose employed was too low to induce a net negative iron balance in this regularly transfused population of pediatric patients with transfusion-dependent beta-thalassemia major, and pharmacokinetic data support a once-daily dosing regimen based on body weight.
Journal ArticleDOI
Once-Daily Treatment with the Oral Iron Chelator ICL670 (Exjade®): Results of a Phase II Study in Pediatric Patients with β-Thalassemia Major.
Antonio Piga,Renzo Galanello,Maria Loreta Foschini,Antonella Zappu,Elena Bordone,Filomena Longo,Gian Luca Forni,Antonella Lavagetto,Yves Bertrand,Henry Maseruka,Nicola Latham,Daniele Alberti +11 more
TL;DR: ICL670 (deferasirox) is an investigational, once-daily oral iron chelator which has been shown to effectively and selectively mobilize tissue iron in adults with transfusional hemosiderosis.
Journal ArticleDOI
Whole liver iron overload measurement by a non cryogenic magnetic susceptometer
Mauro Marinelli,Barbara Gianesin,Martina Lamagna,Antonella Lavagetto,Eraldo Oliveri,M. L. Saccone,G. Sobrero,Laura Terenzani,G. L. Forni +8 more
TL;DR: The data obtained shows that this susceptometer is a reliable instrument for the diagnosis of liver iron overload and for the follow-up further treatment, and is simple to operate, managed directly in the Clinical Center and more affordable than other competing techniques.