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Antonia M. Joussen
Researcher at Charité
Publications - 258
Citations - 6189
Antonia M. Joussen is an academic researcher from Charité. The author has contributed to research in topics: Macular degeneration & Visual acuity. The author has an hindex of 39, co-authored 237 publications receiving 5290 citations. Previous affiliations of Antonia M. Joussen include Boston Children's Hospital & Massachusetts Eye and Ear Infirmary.
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Journal ArticleDOI
Retinal Vascular Endothelial Growth Factor Induces Intercellular Adhesion Molecule-1 and Endothelial Nitric Oxide Synthase Expression and Initiates Early Diabetic Retinal Leukocyte Adhesion in Vivo
Antonia M. Joussen,Antonia M. Joussen,Antonia M. Joussen,Vassiliki Poulaki,Vassiliki Poulaki,Wenying Qin,Wenying Qin,Bernd Kirchhof,Nicholas Mitsiades,Stanley J. Wiegand,John S. Rudge,George D. Yancopoulos,Anthony P. Adamis,Anthony P. Adamis +13 more
TL;DR: VEGF induces retinal ICAM-1 and eNOS expression and initiates early diabetic retinal leukocyte adhesion in vivo and reduces diabetes-related nitric oxide increases in the retinae of diabetic animals.
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Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1α and VEGF
Vassiliki Poulaki,Wenying Qin,Antonia M. Joussen,Peter Hurlbut,Stanley J. Wiegand,John S. Rudge,George D. Yancopoulos,Anthony P. Adamis +7 more
TL;DR: These data are the first to identify a specific mechanism for the transient worsening of diabetic retinopathy, specifically blood-retinal barrier breakdown, that follows the institution of intensive insulin therapy.
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Non-responders to bevacizumab (Avastin) therapy of choroidal neovascular lesions.
TL;DR: The efficiency of bevacizumab depends on initial lesion size and initial reading ability, but is independent of the amount of intraretinal and subretinal fluid, while only patients with the classic type of CNV seemed to respond better.
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Contribution of TNF-alpha to leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis in vivo.
Kan Koizumi,Vassiliki Poulaki,S Doehmen,Gerhard Welsandt,Sven Radetzky,Alexandra Lappas,Norbert Kociok,Bernd Kirchhof,Antonia M. Joussen +8 more
TL;DR: Anti-TNF-alpha treatment reduces the LPS-induced increases in leukocyte rolling, adhesion, and vascular leakage in this rat model of inflammatory uveitis, suggesting the involvement of TNF- alpha in inflammatory uventus and its potential use as a therapeutic agent in the reduction of ocular inflammation.
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Thalidomide inhibits corneal angiogenesis induced by vascular endothelial growth factor.
Friedrich E. Kruse,Antonia M. Joussen,Klaus Rohrschneider,Matthias D. Becker,Hans E. Völcker +4 more
TL;DR: Thalidomide has a significant antiangiogenic effect against VEGF-induced neovasclar growth, which indicates that the drug inhibits two angiogenic pathways which are mediated through integrin adhesion molecules.