Antonino Cacace

TL;DR: Overall, structure-activity relationship (SAR) studies demonstrated that the (R)-epimer of 6C-dimethyl-imidazole (1R)-11 was the most potent and efficient anti-inflammatory agent, among the ten compounds tested.

TL;DR: Evidence from human studies and experimental models support the hypothesis that endogenously generated SPMs or synthetic mimetics of their activities may represent lead molecules in a new discipline, namely the ‘resolution pharmacology,’ offering hope for new therapeutic strategies to prevent and treat diabetes-associated atherosclerosis, nephropathy and retinopathy.

TL;DR: A comprehensive overview of recent progress made in the development of FPR2/ALX agonists which promote resolution and tissue regeneration can be found in this article, where the focus of the review is to provide a comprehensive overview.

TL;DR: SPMs not only attenuate the development of fibrosis through promoting the resolution of inflammation but may also directly suppress fibrotic responses, suggesting novel therapeutic paradigms to treat intractable life-limiting diseases such as renal fibrosis.

TL;DR: Delayed therapeutic administration of RvE1 to mice with polymicrobial sepsis attenuates the cardiac dysfunction through modulating immuno-inflammatory responses, and the ability to enhance bacterial clearance makes R vE1 an ideal therapeutic to reduce the sequalae of polymicro microbial sepsi.