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Antonio Alcaro

Researcher at Sapienza University of Rome

Publications -  17
Citations -  1651

Antonio Alcaro is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Amphetamine & Dopamine. The author has an hindex of 13, co-authored 17 publications receiving 1499 citations. Previous affiliations of Antonio Alcaro include Bowling Green State University.

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Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective.

TL;DR: The affective neuroethological perspective presented here views the ML-DA system in terms of its ability to activate an instinctual emotional appetitive state (SEEKING) evolved to induce organisms to search for all varieties of life-supporting stimuli and to avoid harms.
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The SEEKING mind: Primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression

TL;DR: Abnormal manifestation of SEEKING and its neural substrates are evident in clinical depression and addiction, while addictions reflect re-organizations of the SEEKING disposition around ultra-specific appetitive memories and compulsive activities.
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Norepinephrine in the Prefrontal Cortex Is Critical for Amphetamine-Induced Reward and Mesoaccumbens Dopamine Release

TL;DR: Results indicate that noradrenergic prefrontal transmission, by allowing increased dopamine release in the nucleus accumbens induced by amphetamine, is a critical factor for the rewarding–reinforcing effects of this drug.
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Is subcortical-cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach

TL;DR: A cross-species translational investigation suggests that resting state hyperactivity in depression occurs in subcortical and cortical midline regions and is mediated by glutamate and GABA metabolism.
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Dopamine β-hydroxylase knockout mice have alterations in dopamine signaling and are hypersensitive to cocaine

TL;DR: Antagonists of DA, but not 5-HT, receptors attenuated the locomotor hypersensitivity to cocaine in Dbh−/− mice, which has implications for the influence of genetic and pharmacological DBH inhibition on DA system function and drug addiction.