Anuja Premawardhena

TL;DR: By studying three families with unusual deletions in the β-globin locus, an intergenic region near the δ-globar gene that is necessary for fetal hemoglobin silencing is identified.

TL;DR: Use of 0.25 ml of 1:1000 adrenaline given subcutaneously immediately before administration of antivenom serum to patients with envenomation after snake bite reduces the incidence of acute adverse reactions to serum.

TL;DR: In Sri Lanka, interactions of the two common beta-thalassaemia alleles will nearly always result in a transfusion-dependent disorder, and about 40% of patients will have HbE/beta thalassAemia, which has a variable course.

TL;DR: Those populations with a high frequency of hemoglobin E-beta-thalassemia and related disorders that are at increased risk for hyperbilirubinemia and gall bladder disease are defined and evolutionary insights into how these polymorphisms have arisen and are so unequally distributed among human populations are provided.

TL;DR: It is suggested that in many patients, haemoglobin E β‐thalassaemia can be managed without transfusion, even with low haemochemistry levels, and age‐related changes in the pattern of adaptation to anaemia suggest that more cost‐effective approaches to management should be explored.