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April M. Clayton
Researcher at Johns Hopkins University
Publications - 5
Citations - 712
April M. Clayton is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Anopheles & Anopheles gambiae. The author has an hindex of 5, co-authored 5 publications receiving 624 citations.
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Journal ArticleDOI
Natural Microbe-Mediated Refractoriness to Plasmodium Infection in Anopheles gambiae
Chris M. Cirimotich,Yuemei Dong,April M. Clayton,Simone L. Sandiford,Jayme A. Souza-Neto,Musapa Mulenga,George Dimopoulos +6 more
TL;DR: An Enterobacter bacterium isolated from wild mosquito populations in Zambia is identified that renders the mosquito resistant to infection with the human malaria parasite Plasmodium falciparum by interfering with parasite development before invasion of the midgut epithelium.
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The Anopheles innate immune system in the defense against malaria infection.
TL;DR: This review will discuss the current understanding of the Anopheles mosquito's innate immune responses against the malaria parasite Plasmodium and the influence of the insect's intestinal microbiota on parasite infection.
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Caudal is a negative regulator of the Anopheles IMD Pathway that controls resistance to Plasmodium falciparum infection
TL;DR: In this article, the midgut-specific transcription factor Caudal acts as a negative regulator in the Imd pathway-mediated immune response against the human malaria parasite Plasmodium falciparum.
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A natural Anopheles-associated Penicillium chrysogenum enhances mosquito susceptibility to Plasmodium infection.
Yesseinia I. Angleró-Rodríguez,Benjamin J. Blumberg,Yuemei Dong,Simone L. Sandiford,Andrew Pike,April M. Clayton,George Dimopoulos +6 more
TL;DR: This is the first report of a mosquito-associated fungus that can suppress the mosquito’s innate immune system in a way that would favor Plasmodium infection and possibly malaria transmission.
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Low- and High-Tech Approaches to Control Plasmodium Parasite Transmission by Anopheles Mosquitoes
TL;DR: Research on two approaches to malaria control are summarized, a low-tech strategy based on parasite inhibition by the mosquito's natural microflora, and a high- tech strategy using genetic modification of mosquitoes that renders them resistant to infection and discuss advantages and disadvantages for both approaches.