J
Jayme A. Souza-Neto
Researcher at Sao Paulo State University
Publications - 43
Citations - 2763
Jayme A. Souza-Neto is an academic researcher from Sao Paulo State University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 31 publications receiving 2265 citations. Previous affiliations of Jayme A. Souza-Neto include Johns Hopkins University.
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An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense
TL;DR: The data suggest that the JAK-STAT pathway is part of the A. aegypti mosquito's anti-dengue defense and may act independently of the Toll pathway and the RNAi-mediated antiviral defenses.
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Natural Microbe-Mediated Refractoriness to Plasmodium Infection in Anopheles gambiae
Chris M. Cirimotich,Yuemei Dong,April M. Clayton,Simone L. Sandiford,Jayme A. Souza-Neto,Musapa Mulenga,George Dimopoulos +6 more
TL;DR: An Enterobacter bacterium isolated from wild mosquito populations in Zambia is identified that renders the mosquito resistant to infection with the human malaria parasite Plasmodium falciparum by interfering with parasite development before invasion of the midgut epithelium.
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Discovery of insect and human dengue virus host factors
October M. Sessions,Nicholas J. Barrows,Jayme A. Souza-Neto,Timothy J. Robinson,Christine L. Hershey,Mary A. Rodgers,Jose Luis Ramirez,George Dimopoulos,Priscilla L. Yang,James L. Pearson,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco +11 more
TL;DR: This work identifies insect host factors required for DENV-2 propagation, by carrying out a genome-wide RNA interference screen in Drosophila melanogaster cells using a well-established double-stranded RNA library, and suggests new approaches to control infection in the insect vector and the mammalian host.
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Reciprocal tripartite interactions between the Aedes aegypti midgut microbiota, innate immune system and dengue virus influences vector competence.
Jose Luis Ramirez,Jayme A. Souza-Neto,Rolando Torres Cosme,Jose R. Rovira,Alma Ortiz,Juan Miguel Pascale,George Dimopoulos +6 more
TL;DR: It is shown that the mosquito's microbiota influences dengue virus infection of the mosquito, which in turn activates its antibacterial responses, which influences the microbial load of the mosquitoes midgut.
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Aedes aegypti vector competence studies: A review.
TL;DR: This large literature including studies on the effect of the mosquito microbiota on competence is reviewed, showing that it would be a great advance in this type of research to implement standardized procedures in order to obtain comparable and reproducible results.