A
April M. Griffin
Researcher at Harvard University
Publications - 4
Citations - 2084
April M. Griffin is an academic researcher from Harvard University. The author has contributed to research in topics: Vesicle & Corpus albicans. The author has an hindex of 4, co-authored 4 publications receiving 1911 citations.
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Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
Jan E. Carette,Jan E. Carette,Matthijs Raaben,Anthony C. Wong,Andrew S. Herbert,Gregor Obernosterer,Gregor Obernosterer,Nirupama Mulherkar,Ana I. Kuehne,Philip J. Kranzusch,April M. Griffin,Gordon Ruthel,Paola Dal Cin,John M. Dye,Sean P. J. Whelan,Kartik Chandran,Thijn R. Brummelkamp,Thijn R. Brummelkamp +17 more
TL;DR: It is shown that membrane fusion mediated by filovirus glycoproteins and viral escape from the vesicular compartment require the NPC1 protein, independent of its known function in cholesterol transport, which indicates potential antiviral strategies to combat these deadly agents.
Journal ArticleDOI
Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease
Anthone W. Dunah,Hyunkyung Jeong,April M. Griffin,Yong Man Kim,David G. Standaert,Steven M. Hersch,M. Maral Mouradian,Anne B. Young,Naoko Tanese,Dimitri Krainc +9 more
TL;DR: Coexpression of Sp1 and TAFII130 in cultured striatal cells from wild-type and HD transgenic mice reverses the transcriptional inhibition of the dopamine D2 receptor gene caused by mutant huntingtin, as well as protects neurons from huntingtin-induced cellular toxicity.
Journal ArticleDOI
A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating
TL;DR: It is proposed that, when a diffusion barrier is established at the constricting neck of a fully formed coated pit and immediately after vesicle budding, accumulation of a specific lipid can recruit sufficient auxilin molecules to trigger uncoating.
Journal ArticleDOI
The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation.
TL;DR: A pescadillo homolog is found to act in fungal morphogenesis, specifically in lateral yeast growth on filamentous cells, which is critical for completion of the C. albicans life cycle, in which the fungus switches between filamentous and yeast growth.