A
Arabel Vollmann-Zwerenz
Researcher at University Hospital Regensburg
Publications - 18
Citations - 500
Arabel Vollmann-Zwerenz is an academic researcher from University Hospital Regensburg. The author has contributed to research in topics: Glioma & Cell growth. The author has an hindex of 10, co-authored 14 publications receiving 298 citations.
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Journal ArticleDOI
Tumor Cell Invasion in Glioblastoma.
TL;DR: A comprehensive understanding of glioma invasion mechanisms with respect to tumor-cell-intrinsic properties as well as cues provided by the microenvironment is provided.
Journal ArticleDOI
Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro.
Corinna Seliger,Petra Leukel,Sylvia Moeckel,Birgit Jachnik,Claudio Lottaz,Marina Kreutz,Alexander Brawanski,Martin Proescholdt,Ulrich Bogdahn,Anja-Katrin Bosserhoff,Arabel Vollmann-Zwerenz,Peter Hau +11 more
TL;DR: A regulatory cascade between lactate, THBS-1 and TGF-beta2, leading to enhanced migration of glioma cells is defined, demonstrating a specific interaction between tumor metabolism and migration and providing a better understanding of the mechanisms underlyingglioma cell invasion.
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Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation
Verena Leidgens,Judith Proske,Lisa Rauer,Sylvia Moeckel,Kathrin Renner,Ulrich Bogdahn,Markus J. Riemenschneider,Martin Proescholdt,Arabel Vollmann-Zwerenz,Peter Hau,Corinna Seliger +10 more
TL;DR: Combined specific and unspecific inhibition of STAT3 might represent a promising new strategy in the treatment of glioblastoma.
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Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms.
Verena Leidgens,Corinna Seliger,Birgit Jachnik,Tobias Welz,Petra Leukel,Arabel Vollmann-Zwerenz,Ulrich Bogdahn,Marina Kreutz,Oliver M. Grauer,Peter Hau +9 more
TL;DR: It is postulate that ibuprofen may inhibit tumor cells also by COX- and lactate-independent mechanisms after long-term treatment in physiological dosages, whereas diclofenac mainly acts by inhibition of STAT-3 signaling and downstream modulation of glycolysis.
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Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2.
Corinna Seliger,Anne-Louise Meyer,Kathrin Renner,Verena Leidgens,Sylvia Moeckel,Birgit Jachnik,Katja Dettmer,Ulrike Tischler,Valeria Gerthofer,Lisa Rauer,Martin Uhl,Martin Proescholdt,Ulrich Bogdahn,Markus J. Riemenschneider,Peter J. Oefner,Marina Kreutz,Arabel Vollmann-Zwerenz,Peter Hau +17 more
TL;DR: It seems that metformin does not exert its inhibitory effects on GBM BTIC proliferation and migration by altering TGF-β2-signaling, and further exploration of predictors of BTICs' susceptibility to meetformin appears justified.