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Aram Prokop
Researcher at Boston Children's Hospital
Publications - 116
Citations - 3370
Aram Prokop is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Apoptosis & Leukemia. The author has an hindex of 31, co-authored 105 publications receiving 2963 citations. Previous affiliations of Aram Prokop include East China University of Science and Technology & University of Cologne.
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Journal ArticleDOI
Benzimidazol-2-ylidene Gold(I) Complexes Are Thioredoxin Reductase Inhibitors with Multiple Antitumor Properties
Riccardo Rubbiani,Igor Kitanovic,Hamed Alborzinia,Suzan Can,Ana Kitanovic,Liliane A. Onambele,Maria Stefanopoulou,Yvonne Geldmacher,William S. Sheldrick,Gerhard Wolber,Aram Prokop,Stefan Wölfl,Ingo Ott +12 more
TL;DR: Investigation of gold(I) complexes with benzimidazole derived N-heterocyclic carbene (NHC) ligands represent a promising class of gold coordination compounds with a good stability against the thiol glutathione.
Journal ArticleDOI
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.
Thomas Wieder,Frank Essmann,Frank Essmann,Frank Essmann,Aram Prokop,Aram Prokop,Aram Prokop,Karin Schmelz,Karin Schmelz,Karin Schmelz,Klaus Schulze-Osthoff,Klaus Schulze-Osthoff,Klaus Schulze-Osthoff,Rudi Beyaert,Rudi Beyaert,Rudi Beyaert,Bernd Dörken,Bernd Dörken,Bernd Dörken,Peter T. Daniel,Peter T. Daniel,Peter T. Daniel +21 more
TL;DR: Data indicate that drug-induced caspase-8 activation in B-lymphoma cells is independent of death receptor signaling and is mediated by postmitochondrial casp enzyme-3 activation.
Journal ArticleDOI
Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts
Thomas Wieder,Aram Prokop,B Bagci,Frank Essmann,D Bernicke,Klaus Schulze-Osthoff,Bernd Dörken,Hans-Günther Schmalz,Peter T. Daniel,Günter Henze +9 more
TL;DR: It is shown that resveratrol, as well as the hydroxylated analog piceatannol, are potent inducers of apoptotic cell death in BJAB Burkitt-like lymphoma cells with an ED50 concentration of 25 μM.
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A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor.
Ingo Ott,Xuhong Qian,Yufang Xu,Danielle H. W. Vlecken,Ines J. Marques,Dominic Kubutat,Joanna Will,William S. Sheldrick,Patrick Jesse,Aram Prokop,Christoph P. Bagowski +10 more
TL;DR: Mechanistic experiments indicated that the inhibition of thioredoxin reductase (based on the covalent binding of a gold triethylphosphine fragment) might be involved in the pharmacodynamic behavior of this novel gold species.
Journal ArticleDOI
Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo.
Aram Prokop,Thomas Wieder,Isrid Sturm,Frank Essmann,K Seeger,Christian Wuchter,Wolf-Dieter Ludwig,Günter Henze,Bernd Dörken,Peter T. Daniel +9 more
TL;DR: It is concluded that in ALL relapse a severe disturbance of apoptotic pathways occurs, both at the level of Bax expression and caspase-3 activation.