Suzan Can

TL;DR: Investigation of gold(I) complexes with benzimidazole derived N-heterocyclic carbene (NHC) ligands represent a promising class of gold coordination compounds with a good stability against the thiol glutathione.

TL;DR: Remarkable antiproliferative effects, a strong induction of apoptosis, and enhancement of reactive oxygen species (ROS) formation as well as other effects on tumor cell metabolism confirmed the promising potential of the complexes as novel anticancer chemotherapeutics.

TL;DR: A pilot study aimed at establishing the biological profile of alkynyl phosphine gold(I) complexes shows that the critical target enzyme thioredoxin reductase can be efficiently and selectively inhibited and that cysteine and selenocysteine residues are presumably the sites of molecular interaction with the enzyme.

TL;DR: The data demonstrate that MC3 efficiently suppressed cell growth, and induced cell cycle arrest and apoptosis in pancreatic cancer cells, in particular in the gemcitabine-resistant cancer cells Panc1 and ASPC1.

TL;DR: Intriguingly, cisplatin-resistance in p53-mutant MDA-MB231 breast cancer cells could be overcome by the Au-peptide conjugates presented here, as indicated by flow cytometry, low mitochondrial membrane potential (MMP) and DNA fragmentation.