A
Aravinda K. Chavalmane
Researcher at University of Florence
Publications - 16
Citations - 1148
Aravinda K. Chavalmane is an academic researcher from University of Florence. The author has contributed to research in topics: RHOA & Rho-associated protein kinase. The author has an hindex of 15, co-authored 16 publications receiving 1083 citations.
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Journal ArticleDOI
Testosterone partially ameliorates metabolic profile and erectile responsiveness to PDE5 inhibitors in an animal model of male metabolic syndrome.
Sandra Filippi,Linda Vignozzi,Annamaria Morelli,Aravinda K. Chavalmane,Erica Sarchielli,Benedetta Fibbi,Farid Saad,Peter Sandner,Peggy Ruggiano,Gabriella B. Vannelli,Edoardo Mannucci,Mario Maggi +11 more
TL;DR: T treatment dramatically reduced HFD-induced visceral obesity, partially ameliorating also the metabolic profile and PDE5 and eNOS mRNA expression quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) were significantly decreased.
Journal ArticleDOI
Characterization of Phosphodiesterase Type 5 Expression and Functional Activity in the Human Male Lower Urinary Tract
Benedetta Fibbi,Annamaria Morelli,Linda Vignozzi,Sandra Filippi,Aravinda K. Chavalmane,Giulia De Vita,Mirca Marini,Mauro Gacci,Gabriella B. Vannelli,Peter Sandner,Mario Maggi +10 more
TL;DR: The highest expression and biological activity of PDE5 was found in bladder, however, a consistent Pde5 expression and activity was also found in prostatic urethra.
Testosterone partially ameliorates metabolic profile and erectile responsiveness to PDE5 inhibitors in an animal model of male metabolic syndrome
Linda Vignozzi,Sandra Filippi,Annamaria Morelli,Aravinda K. Chavalmane,Erica Sarchielli,Gabriella B. Vannelli,Edoardo Mannucci,Mario Maggi +7 more
Journal ArticleDOI
The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways.
Giuseppe Penna,Benedetta Fibbi,Susana Amuchastegui,Elisa Corsiero,Gilles Laverny,Enrico Silvestrini,Aravinda K. Chavalmane,Annamaria Morelli,Erica Sarchielli,Gabriella B. Vannelli,Mauro Gacci,Enrico Colli,Mario Maggi,Luciano Adorini +13 more
TL;DR: The vitamin D receptor (VDR) agonist elocalcitol can arrest prostate growth in BPH patients, but its mechanism of action in this pathology is still incompletely understood.
Journal ArticleDOI
Atorvastatin Ameliorates Sildenafil-Induced Penile Erections in Experimental Diabetes by Inhibiting Diabetes-Induced RhoA/Rho-Kinase Signaling Hyperactivation
Annamaria Morelli,Aravinda K. Chavalmane,Sandra Filippi,Benedetta Fibbi,Enrico Silvestrini,Erica Sarchielli,Xin-Hua Zhang,Linda Vignozzi,Gabriella B. Vannelli,Gianni Forti,Mario Maggi +10 more
TL;DR: Atorvastatin improves diabetes-related ED and restores sildenafil responsiveness, most probably by inhibiting RhoA/ROCK signaling, which underlies several high-glucose-induced derangements in penile smooth muscle cell commitment.