E
Enrico Silvestrini
Researcher at University of Florence
Publications - 9
Citations - 536
Enrico Silvestrini is an academic researcher from University of Florence. The author has contributed to research in topics: RHOA & Rho-associated protein kinase. The author has an hindex of 9, co-authored 9 publications receiving 506 citations.
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Journal ArticleDOI
The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways.
Giuseppe Penna,Benedetta Fibbi,Susana Amuchastegui,Elisa Corsiero,Gilles Laverny,Enrico Silvestrini,Aravinda K. Chavalmane,Annamaria Morelli,Erica Sarchielli,Gabriella B. Vannelli,Mauro Gacci,Enrico Colli,Mario Maggi,Luciano Adorini +13 more
TL;DR: The vitamin D receptor (VDR) agonist elocalcitol can arrest prostate growth in BPH patients, but its mechanism of action in this pathology is still incompletely understood.
Journal ArticleDOI
Atorvastatin Ameliorates Sildenafil-Induced Penile Erections in Experimental Diabetes by Inhibiting Diabetes-Induced RhoA/Rho-Kinase Signaling Hyperactivation
Annamaria Morelli,Aravinda K. Chavalmane,Sandra Filippi,Benedetta Fibbi,Enrico Silvestrini,Erica Sarchielli,Xin-Hua Zhang,Linda Vignozzi,Gabriella B. Vannelli,Gianni Forti,Mario Maggi +10 more
TL;DR: Atorvastatin improves diabetes-related ED and restores sildenafil responsiveness, most probably by inhibiting RhoA/ROCK signaling, which underlies several high-glucose-induced derangements in penile smooth muscle cell commitment.
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Vardenafil Modulates Bladder Contractility Through cGMP-mediated Inhibition of RhoA/Rho Kinase Signaling Pathway in Spontaneously Hypertensive Rats
Annamaria Morelli,Sandra Filippi,Peter Sandner,Benedetta Fibbi,Aravinda K. Chavalmane,Enrico Silvestrini,Erica Sarchielli,Linda Vignozzi,Mauro Gacci,Marco Carini,Gabriella B. Vannelli,Mario Maggi +11 more
TL;DR: This is the first study demonstrating that the effect of vardenafil on OAB could be partially determined by a cGMP-dependent RhoA/ROCK signaling inhibition.
Journal ArticleDOI
Acute Vardenafil Administration Improves Bladder Oxygenation in Spontaneously Hypertensive Rats
Annamaria Morelli,Sandra Filippi,Paolo Comeglio,Erica Sarchielli,Aravinda K. Chavalmane,Linda Vignozzi,Benedetta Fibbi,Enrico Silvestrini,Peter Sandner,Mauro Gacci,Marco Carini,Gabriella B. Vannelli,Mario Maggi +12 more
TL;DR: Rat bladder bladder showed bladder hypoxia which was significantly reduced by acute vardenafil treatment, suggesting that besides relaxing muscular wall, PDE5 inhibition may positively affect urinary vesicle blood perfusion.
Journal ArticleDOI
Atorvastatin but not elocalcitol increases sildenafil responsiveness in spontaneously hypertensive rats by regulating the RhoA/ROCK pathway.
Benedetta Fibbi,Annamaria Morelli,Mirca Marini,Xin-Hua Zhang,Rosa Mancina,Linda Vignozzi,Sandra Filippi,Aravinda K. Chavalmane,Enrico Silvestrini,Enrico Colli,Luciano Adorini,Gabriella B. Vannelli,Mario Maggi +12 more
TL;DR: Atorvastatin, but not elocalcitol, ameliorates sildenafil-induced penile erections in SHR, likely by interfering with RhoA/ROCK signaling within the penis.