A
Arianna Perez
Researcher at Nova Southeastern University
Publications - 7
Citations - 79
Arianna Perez is an academic researcher from Nova Southeastern University. The author has contributed to research in topics: Signal transduction & Receptor. The author has an hindex of 4, co-authored 7 publications receiving 37 citations.
Papers
More filters
Journal ArticleDOI
Deletion of Osteopontin Enhances β₂-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes.
Celina M. Pollard,Victoria L Desimine,Shelby L Wertz,Arianna Perez,Barbara M Parker,Jennifer Maning,Katie A McCrink,Lina A. Shehadeh,Anastasios Lymperopoulos +8 more
TL;DR: A direct inhibitory role of OPN is uncovered in cardiac β2AR anti-fibrotic signaling via cAMP/Epac1 in H9c2 rat cardiac myoblasts, which could be of value in the treatment and/or prevention of cardiac fibrosis.
Journal ArticleDOI
Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition
Jennifer Maning,Katie A McCrink,Celina M. Pollard,Victoria L Desimine,Jennifer Ghandour,Arianna Perez,Natalie Cora,Krysten E Ferraino,Barbara M Parker,Ava Brill,Beatrix Aukszi,Anastasios Lymperopoulos +11 more
TL;DR: In this article, the authors investigated whether GPCR-kinase-2 and -5 phosphorylates and inhibits the mineralocorticoid receptor (MR) but also activates the G protein-coupled estrogen receptor (GPER) in the heart.
Journal ArticleDOI
The place of ARBs in heart failure therapy: is aldosterone suppression the key?
Uma Markan,Samhitha Pasupuleti,Celina M. Pollard,Arianna Perez,Beatrix Aukszi,Anastasios Lymperopoulos +5 more
TL;DR: The present short review gives an overview of the clinical properties of the ARBs currently approved by the United States Food and Drug Administration, with a particular focus on candesartAn and valsartan and the areas where these two drugs seem to have a therapeutic edge.
Journal ArticleDOI
GRK2-Mediated Crosstalk Between β-Adrenergic and Angiotensin II Receptors Enhances Adrenocortical Aldosterone Production In Vitro and In Vivo.
Celina M. Pollard,Jennifer Ghandour,Natalie Cora,Arianna Perez,Barbara M Parker,Victoria L Desimine,Shelby L Wertz,Janelle M Pereyra,Krysten E Ferraino,Jainika J Patel,Anastasios Lymperopoulos +10 more
TL;DR: It is suggested that adrenal GRK2 may be a molecular link connecting the sympathetic nervous and renin-angiotensin systems at the level of the adrenal cortex and that its inhibition might be therapeutically advantageous in hyperaldosteronism-related conditions.