V
Victoria L Desimine
Researcher at Nova Southeastern University
Publications - 22
Citations - 175
Victoria L Desimine is an academic researcher from Nova Southeastern University. The author has contributed to research in topics: Signal transduction & G protein-coupled receptor. The author has an hindex of 5, co-authored 17 publications receiving 100 citations.
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Journal ArticleDOI
Deletion of Osteopontin Enhances β₂-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes.
Celina M. Pollard,Victoria L Desimine,Shelby L Wertz,Arianna Perez,Barbara M Parker,Jennifer Maning,Katie A McCrink,Lina A. Shehadeh,Anastasios Lymperopoulos +8 more
TL;DR: A direct inhibitory role of OPN is uncovered in cardiac β2AR anti-fibrotic signaling via cAMP/Epac1 in H9c2 rat cardiac myoblasts, which could be of value in the treatment and/or prevention of cardiac fibrosis.
Book ChapterDOI
Biased Agonism/Antagonism of Cardiovascular GPCRs for Heart Failure Therapy.
Victoria L Desimine,Katie A McCrink,Barbara M Parker,Shelby L Wertz,Jennifer Maning,Anastasios Lymperopoulos +5 more
TL;DR: This chapter summarizes the GPCR signaling pathways and their biased agonism/antagonism examples discovered so far that can be exploited for heart failure treatment and highlights important issues that need to be clarified along the journey of these ligands from bench to the clinic.
Journal ArticleDOI
Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and Disease.
Barbara M Parker,Shelby L Wertz,Celina M. Pollard,Victoria L Desimine,Jennifer Maning,Jennifer Maning,Katie A McCrink,Katie A McCrink,Anastasios Lymperopoulos +8 more
TL;DR: This review summarizes the current experimental evidence for this GPCR-MR crosstalk in the heart and discusses its pathophysiological implications for cardiac adverse remodeling as well as for heart disease therapy.
Journal ArticleDOI
Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart.
Anastasios Lymperopoulos,Shelby L Wertz,Celina M. Pollard,Victoria L Desimine,Jennifer Maning,Katie A McCrink +5 more
TL;DR: Design of novel cardiac GPCR ligands that preferentially activate β-arrestin-2 over β-arsenin-1 has the potential of generating novel cardiovascular therapeutics for heart failure and other heart diseases.
Journal ArticleDOI
Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition
Jennifer Maning,Katie A McCrink,Celina M. Pollard,Victoria L Desimine,Jennifer Ghandour,Arianna Perez,Natalie Cora,Krysten E Ferraino,Barbara M Parker,Ava Brill,Beatrix Aukszi,Anastasios Lymperopoulos +11 more
TL;DR: In this article, the authors investigated whether GPCR-kinase-2 and -5 phosphorylates and inhibits the mineralocorticoid receptor (MR) but also activates the G protein-coupled estrogen receptor (GPER) in the heart.