Arianna Pocaterra

TL;DR: Findings suggest that aerobic glycolysis endows cancer cells with particular metabolic properties and at the same time sustains transcription factors with potent pro‐tumorigenic activities such as YAP/TAZ.

TL;DR: A hitchhiker's guide to the rapidly expanding YAP/TAZ regulatory network, centered on the Hippo pathway and on mechanosensing of the physical properties of the cell microenvironment.

TL;DR: Current data linking YAP/TAZ to metabolism is discussed and it is suggested how this coupling might coordinate nutrient availability with genetic programs that sustain tissue growth, neoplastic cell proliferation, and tumor malignancy.

TL;DR: A general mechanism centered on Lipin-1 and SREBP is identified that links the physical cell microenvironment to a key metabolic pathway and contributes to the pro-survival activity of ROCK inhibitors in pluripotent stem cells.

TL;DR: YAP/TAZ couples cell proliferation with a metabolism suited for DNA replication and facilitates escape from oncogene‐induced senescence, and this study indicates that this activity might be relevant during the initial phases of tumour progression or during experimental stem cell reprogramming induced by YAP.