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Elena Enzo
Researcher at University of Modena and Reggio Emilia
Publications - 23
Citations - 7703
Elena Enzo is an academic researcher from University of Modena and Reggio Emilia. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 14, co-authored 19 publications receiving 6255 citations. Previous affiliations of Elena Enzo include University of Padua.
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Journal ArticleDOI
Role of YAP/TAZ in mechanotransduction
Sirio Dupont,Leonardo Morsut,Mariaceleste Aragona,Elena Enzo,Stefano Giulitti,Michelangelo Cordenonsi,Francesca Zanconato,Jimmy Le Digabel,Mattia Forcato,Silvio Bicciato,Nicola Elvassore,Stefano Piccolo +11 more
TL;DR: YAP/TAZ are identified as sensors and mediators of mechanical cues instructed by the cellular microenvironment and are functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and for survival of endothelial cells regulated by cell geometry.
Journal ArticleDOI
YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response
Luca Azzolin,Tito Panciera,Sandra Soligo,Elena Enzo,Silvio Bicciato,Sirio Dupont,Silvia Bresolin,Chiara Frasson,Giuseppe Basso,Vincenza Guzzardo,Ambrogio Fassina,Michelangelo Cordenonsi,Stefano Piccolo +12 more
TL;DR: Evidence is provided that YAP and TAZ are integral components of the β-catenin destruction complex that serves as cytoplasmic sink for YAP/TAZ, revealing an unprecedented signaling framework relevant for organ size control, regeneration, and tumor suppression.
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A MicroRNA targeting dicer for metastasis control.
Graziano Martello,Antonio Rosato,Francesco Ferrari,Andrea Manfrin,Michelangelo Cordenonsi,Sirio Dupont,Elena Enzo,Vincenza Guzzardo,Maria Rondina,Thomas Spruce,Anna Parenti,Maria Grazia Daidone,Silvio Bicciato,Stefano Piccolo +13 more
TL;DR: These findings suggest a new pathway by which Dicer inhibition drifts epithelial cancer toward a less-differentiated, mesenchymal fate to foster metastasis, and attenuates miRNA biosynthesis by targeting Dicer, a key component of the miRNA processing machinery.
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Regeneration of the entire human epidermis using transgenic stem cells
Tobias Hirsch,Tobias Rothoeft,Norbert Teig,Johann W. Bauer,Graziella Pellegrini,Laura De Rosa,Davide Scaglione,Julia Reichelt,Alfred Klausegger,Daniela Kneisz,Oriana Romano,Alessia Secone Seconetti,Roberta Contin,Elena Enzo,Irena Jurman,Sonia Carulli,Frank Jacobsen,Thomas Luecke,Marcus Lehnhardt,Meike Fischer,Maximilian Kueckelhaus,Daniela Quaglino,Michele Morgante,Silvio Bicciato,Sergio Bondanza,Michele De Luca +25 more
TL;DR: It is shown that autologous transgenic keratinocyte cultures regenerated an entire, fully functional epidermis on a seven-year-old child suffering from a devastating, life-threatening form of JEB, providing a blueprint that can be applied to other stem cell-mediated combined ex vivo cell and gene therapies.
Journal ArticleDOI
BMP signaling controls muscle mass
Roberta Sartori,Elija Schirwis,Bert Blaauw,Sergia Bortolanza,Jinghui Zhao,Elena Enzo,Amalia Stantzou,Amalia Stantzou,Etienne Mouisel,Luana Toniolo,Arnaud Ferry,Sigmar Stricker,Alfred L. Goldberg,Sirio Dupont,Stefano Piccolo,Helge Amthor,Marco Sandri +16 more
TL;DR: It is shown that bone morphogenetic protein (BMP) signaling, acting through Smad1, Smad5 and Smad8 (Smad1/5/8), is the fundamental hypertrophic signal in mice, and a critical role for the BMP pathway in adult muscle maintenance, growth and atrophy is identified.