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Armaz Aschrafi
Researcher at Laboratory of Molecular Biology
Publications - 55
Citations - 3137
Armaz Aschrafi is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Messenger RNA & microRNA. The author has an hindex of 30, co-authored 55 publications receiving 2804 citations. Previous affiliations of Armaz Aschrafi include National Institutes of Health & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis.
John Dresios,Armaz Aschrafi,Geoffrey C. Owens,Peter W. Vanderklish,Gerald M. Edelman,Vincent P. Mauro +5 more
TL;DR: The possibility that Rbm3 expression alters global protein synthesis by affecting microRNA levels is discussed and it is suggested that both RBM3 and microRNAs are part of a homeostatic mechanism that regulates global levels of protein synthesis under normal and cold-stress conditions.
Journal ArticleDOI
MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons
Armaz Aschrafi,Azik D. Schwechter,Marie G. Mameza,Orlangie Natera-Naranjo,Anthony E. Gioio,Barry B. Kaplan +5 more
TL;DR: The results point to a molecular mechanism by which this microRNA participates in the regulation of axonal respiration and function by modulating the levels of COXIV, a protein which plays a key role in the assembly of the mitochondrial cytochrome c oxidase complex IV.
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MicroRNA networks direct neuronal development and plasticity
N.F.M. Olde Loohuis,Aron Kos,Gerard J.M. Martens,H Van Bokhoven,Nael Nadif Kasri,Armaz Aschrafi +5 more
TL;DR: An overview of recently identified mechanisms of neuronal development and plasticity involving miRNAs, and the consequences of miRNA dysregulation is provided.
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Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons.
TL;DR: Compartmentalized Campenot cell culture chambers are employed to obtain a pure axonal RNA fraction of superior cervical ganglia neurons, and the miRNA expression levels in these subcellular structural domains are determined by microarray analysis and by real-time reverse-transcription polymerase chain reaction.
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The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain
TL;DR: In this paper, the role of FMRP in the regulation of mRNA granules was investigated in the context of Fragile X mental retardation protein (FMRP) deficiency.